摘要
细胞膜微粒是细胞激活、受损和/或凋亡时从质膜上脱落的亚微米囊泡。在正常的机体中,它有多种细胞来源(血小板、白细胞、内皮细胞等),但是在病理条件下其数量就会发生改变。内皮微粒是一种内皮细胞源的包膜微粒,新近研究发现它不仅是一种内皮功能紊乱的标记,同时还可能作为一种新的诊疗勃起功能障碍的重要生物标记。
Microparticles are submicron vesicles shed from plasma membranes in response to cell activation,injury and/or apoptosis. Microparticles of various cellular origins,such as platelets,leukocytes,and endothelial cells,are found in the plasma of healthy subjects,and their amount increases under pathological conditions. Recent studies show that endothelial microparticles,a kind of envelope particles derived from endothelial cells,not only constitute a marker of endothelial dysfunction,but also play a major biological role in the diagnostic and therapeutic approaches to erectile dysfunction.
出处
《中华男科学杂志》
CAS
CSCD
2013年第10期945-948,共4页
National Journal of Andrology
基金
国家自然科学基金(81070486/H0415)
四川省杰出青年学术技术带头人培育基金(川科计2010 4号:2010JQ0040)
广东省自然科学基金(10151031701000010)~~
关键词
内皮微粒
勃起功能障碍
诊疗
endothelial microparticle
erectile dysfunction
diagnosis and treatment
