摘要
目的：探讨中西结合治疗毒性弥漫性甲状腺肿（Graves病）合并糖尿病的临床疗效。方法将2010年6月～2011年6月间在山东省东营现河医院门诊或住院治疗的Graves病合并糖尿病患者50例，随机分为观察组和对照组，每组25例。对照组采用常规西医治疗方案，观察组在西医治疗的基础上根据中医理论进行辩证分型，采用对应中药来进行治疗。2组患者均在治疗8周后进行疗效评估。结果观察组总有效率为90%，高于对照组的80%（P<0.05）；治疗后2组胰岛素抵抗指数（homeostasis model assessment-insulin resistance index，HOMA-IR），血清总三碘甲腺原氨酸（total triiodothyronine， TT 3），血清总甲状腺素（total thyroxine，TT 4）水平均明显降低，促甲状腺激素（thyroid stimulating hormone，TSH）明显升高，与治疗前比较，差异均有显著性意义（P<0.01）。治疗组TT 3，TT 4，TSH改善明显优于对照组，差异有显著性意义（P<0.01）。结论中西医结合治疗Graves病合并糖尿病疗效肯定。
Objective To investigate the clinical efifcacy of Chinese and western medicine on toxic diffuse goiter (Graves disease) diabetes mellitus. Methods 50 cases of Graves'' disease and diabetes mellitus collected in Xianhe hospitol of Dongying city,Shandong Province from June 2010 to June 2011 were randomly divided into observation group(n=25) and control group(n=25). Control group was adopted conventional western medicine treatment. Based on western medicine treatment, observation group was, conducted dialectical types according to TCM theory, and used appropriate Chinese medicine to treatment. Efficacy of two groups after 8 weeks treatment were evaluated. Results The total effective rate in observation group was 90%, higher than 80% in control group(P<0.05). Compared with before treatment, insulin resistance index (HOMA-IR), TT 3, TT 4 levels were signiifcantly decreased, and TSH was signiifcantly increased in both two groups(P<0.01). The improvement of TT 3, TT 4, TSH in treatment group were more obvious than control group, and the difference was signiifcant (P<0.01). Conclusion The combination therapy was effective on patients with Graves'' disease and diabetes.
出处
《中国生化药物杂志》
CAS
北大核心
2014年第2期132-134,137,共3页
Chinese Journal of Biochemical Pharmaceutics
