摘要
目的探讨香菇多糖对XELOX方案治疗晚期胃癌疗效的影响。方法将Ⅲ或ⅣV期的晚期胃癌患者分为XEL0X方案治疗组(对照组)和香菇多糖联合XELOX方案治疗组(观察组),比较两组研究对象疗效、毒副反应、WBC、Lym、CD 3^+、CD 4^+、CD 8^+、NK细胞和生存质量差异。结果观察组患者疾病控制率明显高于对照组,但差异无统计学意义。观察组胃肠道反应、骨髓抑制、神经毒性、手足综合征和其他等Ⅲ~Ⅳ级和Ⅰ~Ⅳ级不良反应发生率显著低于对照组(P<0.05)。两组研究对象化疗前的WBC、Lym、CD 3^+、CD 4^+、CD 8^+和NK细胞无明显差异。观察组研究对象化疗3周期和化疗6周期后WBC、Lym、CD 3^+、CD 4^+、CD 8^+和NK细胞均显著高于对照组研究对象(P<0.05)。两组研究对象化疗前的生理状况、社会/家庭状况、情感状况和功能状况评分无明显差异。两组研究对象化疗后的生理状况和情感状况均较化疗前显著降低(P<0.05),社会/家庭状况和功能状况较化疗前显著升高(P<0.05)。观察组患者化疗后的生理状况和情感状况均显著低于对照组(P<0.05),社会/家庭状况和功能状况显著高于对照组(P<0.05)。结论香菇多耱可显著改善晚期胃癌患者免疫功能,增强XELOX方案化疗疗效并降低其毒副反应,提高生存质量。
Objective To study lentinan’s promotion on XELOX regimen’s curative effects on advanced gastric cancer. Method Cases with advanced gastric cancer were divided into observation group and control group according their therapy method. The curative effects, side effects, WBC, lymphocyte subsets, NK cells and quality of life were compared. Results The difference of disease control rates in two groups were not significant (P=0.091). The incidences of side effects in observation group were significantlly lower than in control group (P<0.05). The observation group’s WBC, Lym, CD 3+, CD 4+, CD 8+, NK cells and quality of life were significantly higher than in control group(P<0.05). Conclusion Lentinan could significantly promote gastric cancer patients’immunity and lessen side effects. It can promote XELOX regimen’s curative effects on gastric cancer and improve quality of life.
出处
《中国生化药物杂志》
CAS
北大核心
2014年第1期95-96,99,共3页
Chinese Journal of Biochemical Pharmaceutics
