摘要
本文将脐血胆红素>3mg/dl,～生后24小时>6mg/dl,～48小时>9mg/dl,或每日上升>5mg/dl作为早期监测ABO新生儿溶血病(ABO HDN)引起高胆红素血症(高胆)的胆红素标准,将符合上述标准的ABO HDN 27例,随机分成两组:预防治疗组12例和对照组(常规治疗组)15例,分别于胆红素达到监测标准和超过12mg/dl时给予光疗48～72小时,其结果,前者的高胆发生率及胆红素峰值均降低,病程缩短,减少了核黄疸的危险性。
Ordinarily phototherapy would be given to those icterus infants whose uneonjugated bilirubin levels reach≥12mg/dl, a criteria of hyperbilirubinemia in term infants. In order to find out the preventive effect of early treatment, serum bilirubin levels of 27 term babies of ABO HDN, diagnosed serologically by cord blood were monitored once every day after birth. Critical levels would be considered when the cord blood bilirubin reached>3mg/dl, ～24 hours of life>6mg/dl, ～48 hours>9mg/dl, or increased more than 5mg/dl daily. The infants were divided into 2 groups by random allocation. In the preventive group, 12 cases were given phototherapy immediately as their bilirubin concentration reached the critical levels. In the control group (routine therapy group), treatment would not begin until the bilirubin concentration increased to a level 12mg/dl. Actually only 13 cases of this group received phototherapy since another 2 cases did not have a bilirubin concentration>12mg/dl through course. Continuous exposures to blue fluorescent light were similar in both groups for 48～72 hours. The present study demonstrated that: 1. The incidence of hyperbilirubinemia of the preventive group was significantly lower than that of the control (33.33% VS 86.67%, respectively), (P<0.05). 2. The peak value of serum bilirubin concentration of the preventive group was very significantly lower than that of the control (11.19+2.04mg/dl VS 15.27±2.76mg/dl, respectively), (P=0.0004). 3. The clinical course of hyperbilirubinemia of the preventive group was very significantly shorter than that of the control (5.08+2.02days VS 8.77±2.28days, respectively), (P=0.0003). 4. No significant difference were found between the two groups with the day-to-day change in serum bilirubin concentration through the course (P>0.05).
出处
《中国新生儿科杂志》
CAS
1991年第4期150-152,189,共4页
Chinese Journal of Neonatology
