摘要
为进一步研究甲肝减毒活疫苗的安全性及免疫原性,在小量人体观察(30名志愿者)获得满意结果的基础上,进行了扩大人群的再观察。选350名8～11岁健康学龄儿童,随机分成5个组,对不同接种剂量、不同接种途径及不同滴度的疫苗接种后的反应及效果进行了观察。结果表明,所有受试者均无局部和全身反应,亦无肝酶的异常升高。免后4周,不同剂量、不同途径的抗体阳转率为70～100%,免后8周为98～100%,进一步证实该实验性疫苗是安全的,其免疫原性是良好的。
On the basis of satisfactory results in limited numbers of recipients(30volunt- eers),we observed an enlarged group of 350 healthy school children from age 8—11,who were randomly divided into 5 groups and injected with different doses,and titres by fiffer- ent routes with the experimental hepatitis A vaccine.The results showed that none of the recipients developed any local or systemic adverse reaction,and no abnormal elevation of body temperature or liver enzyme were found.The seroconversion rates at four weeks after immunization ranged from 70—100%,and 98—100% at 8 weeks.It suggested that the exper- imental vaccine was safe with good immunogenicity.
出处
《中国生物制品学杂志》
CAS
CSCD
1991年第4期178-180,共3页
Chinese Journal of Biologicals
关键词
甲肝减毒活疫苗
接种反应
免疫效果
Live attenuated HAV
vaccine
Inoculation reaction
Immune efficacy
