摘要
采用间接免疫荧光技术检测了19例晚期血吸虫病患者脾脏内7干扰素(IFN)分布和含量的变化。发现正常人脾内IFN—γ呈弥漫性分布,可位于细胞内或细胞外间质,而晚期血吸虫病患者脾内IFN—γ仅呈零星散在分布,并且多位于细胞内。经半定量分析,晚期血吸虫病患者脾脏内IFN—γ含量显著减少,提示晚期血吸虫病患者脾内IFN—γ的变化可能在晚期血吸虫病的免疫发病机理中起重要作用。
Interferon-γ(IFN-γ) in the splenic tissue of 19 patients with advanced schi-stosomiasis japonica was detected with indirect immunofluoreScence technique. It was found that IFN-γ in the spleen of normal persons was diffusely distributed, either inside the secretory cells or in the extracellular substance. IFN-γ was scattered and mainly located inside the secretory cells in the spleen of patients with advanced schistosomiasis. Through the semiquantitative analysis, the amount of IFN-γ in the spleen of patients with advanced schistosomiasis japonica was significantly reduced. The results indicate that the changes of IFN-γ in the spleen of patients with advanced schistosomiasis may play an important role in the immunopathogenesis of advanced schistosomiasis japonica.
出处
《中国血吸虫病防治杂志》
CAS
CSCD
1991年第4期206-208,共3页
Chinese Journal of Schistosomiasis Control
