摘要
基于临床使用活血化瘀中药于鼻咽癌患者,通过188例随机分组研究5年治愈率自36.7％提高至53.3 ％,尤以Ⅲ期与Ⅳ期患者显著。而决定使用离体多细胞球体研究活血化瘀中药的增敏使作用。实验用毒性为15 ％的药物剂量(即30my/ml浓度):辐射自1Gy至31Gy分12个剂量组,重复6次实验。结果在低剂量区(0～10Gy)加药组肩段稍变小,10～20Gy时细胞存活曲线稍低于对照组;但当剂量增加时存括曲线明显升高;说明药物的增敏作用不很明显,而在高剂量时可能对辐射有保护作用。
As previously reported, the concomitant use of Destagnation, a group of Chinese herbal medicines, was able to raise the 5-year survival rate of 188 patients with nasopharyngeal carcinoma from 36.7% to 53.3% in a randomized clinical trial. It was valid specially in the advanced lesions (Stages Ⅲ and Ⅳ). In vitro multicell spheroids colony formation method was used in the study of radiosensitizing effect of 764-1. Experiment was repeated six times with the reagent at a toxic dose of ID50% (concentration 30mg/ml) and twelve radiation dose groups ranging from 1 to 30 Gy. The results were: 1. Smaller shoulder segment of survival curve was observed in the lower dose range (0-10 Gy) of the 764-1 group. 2. In the 10-25 Gy range, the survival curve did not show the presence of radiosensitizing effect. 3. The survival curve increased with the radiation dose to more than 20 Gy, so a possible protection against the radiation may be present in higher dose range.
出处
《中华放射肿瘤学杂志》
CSCD
1992年第3期45-46,70,共3页
Chinese Journal of Radiation Oncology
