摘要
对50例支气管哮喘(哮喘)及喘息型支气管炎(喘支)患者,喘息发作时,舌下含化硝苯啶20mg后,120分钟内连续观察肺功能的改变。结果表明,哮喘组在含药后10～120分钟FVC显著增加(P<0.01),喘支组于10～30分钟FVC显著增加(P<0.05),120分钟达高峰(P<0.01)。哮喘组FEV_1于30分钟开始增加,60分钟达高峰(P<0.01),而喘支组于60分钟开始增加,120分钟达高峰。说明哮喘组的肺通气功能较喘支组改善明显。在哮喘组中,FEV_1>35％预计值组,于含药后FVC及FEV_1均显著增加,而FEV_1<35％预计值组,只有FVC的增加。说明硝苯啶含化对哮喘发作病人,特别是病情较轻的病人效果更佳。
The effects of nifedipine on lung ventilatory function were observed in 40 patients with bronchial asthma and 10 patients with chronic asthmatic bronchitis.The results showed that FVC was significantly increased from 10 to 120 minutes after sublingual administration of nifedipine(20mg) in the asthma group(P<0.01),and from 10 to 30 minutes after sublingual administration in the chronic bronchitis group(p<0.05).FEVV_1 began to increase at the 30th minute after sublingual administration and reached the peak at the 60th minute in the asthma group;but in the chronic asthmatic bronchitis group,increase in FEV_1 occurred at the 60th minute and reached the peak at the second hour.In the bronchial asthma patients of FEV_1>35％ prediction value,both FVC and FEV_1 more significantlyincreased after sublingual administration as compared with the patients of FEV_1<35％ prediction value.The results suggest that nifedipine has obvious effects on the patients with bronchial asthma,especially in mild attack.
出处
《承德医学院学报》
1992年第4期241-245,共5页
Journal of Chengde Medical University
关键词
硝苯啶
支气管哮喘
喘息型支气管炎
肺功能
nifedipine
asthma
chronic asthmatic bronchitis
ventilatory function
