摘要
应用放射免疫分析法和侧脑室微量注射技术,观察了精氨酸加压素(AVP)对急性缺血性脑水肿的作用。结果表明,沙土鼠脑缺血15～120min,皮层、纹状体、下丘脑的 AVP 含量均明显升高,缺血不明显的桥延部,AVP 含量则无明显变化;且缺血不同时间的皮层 AVP 含量与皮层水肿呈非常显著的相关性.侧脑室注射AVP 后,缺血性皮层水肿显著加重,并表现为良好的剂量-效应依赖关系.而侧脑室注射 AVP 抗血清后,缺血性皮层水肿明显减轻。提示 AVP 参与了急性缺血性脑水肿的病理生理过程.脑缺血时,脑内 AVP 含量的升高,可加重或促进缺血性脑水肿的形成.
The purpose of this experiments is to study the role of argi- nine vasopressin (AVP) in acute ischemic brain edema of mongolian gerbils. The results showed that the contents of AVP in ischemic cortex,hypothala- mus and striatum increased remarkably in 15～120 minutes after ischemia, while the contents of AVP had no change in pons-medulla vhich was not affected from ischemia,and there was relationship between the contents of AVP in corte(?) and the ischemic cortical edema.Intracerebroventricular inje- ction(ICV) of AVP e acerbated the ischemic cortical edema and it showed dose-response correlation.while ICV of AVP antiserum significantly decrea- sed ischemic cortical edema.These suggested that AVP was involved in the pathophysiologic process of acute ischemic brain edema.The inevement of AVP contents in ischemic brain regions could exacerbate the formation of ischemic brain edema.
出处
《医学研究生学报》
CAS
1992年第1期36-39,93-94,共6页
Journal of Medical Postgraduates
