摘要
25例(35次)急性哮喘发作者(男14例,女11例;年龄为20～68岁)分为中度组(16例次)和重度组(19例次).按首次剂量4～6 mg/kg、维持量0.5～0.7mg.kg^(-1)/h 给予氨茶硷静滴治疗。稳态血氨茶硷浓度在重度组显著高于中度组(18.604±10.383mg/L,11.407±4.839mg/L,P<0.05).茶硷毒副反应的表现和程度,重度组显著高于中度组,两组出现毒副反应的药物浓度分别为28.96mg/L vs 10.62mg/L.作者认为,在相同治疗方案下出现两组间上述差别,与重度哮喘时茶碱的非线性代谢有关,说明对重症哮喘者的药物监测具有特别的重要性.
The twenty five cases of acute severe asthmatics (M:14 F: 11,20-48 yrs) were treated with a common regimen of intravenous amino- phylline infusion (0.25g aminophylline as initial loading dose,than 0.5-0.7mg /kg/hr as maintenance).The clinical presentations,theophylline pharmacoki- netics and toxic adverse effects were analysed. According to Bernstein's criteria,patients were divided into two groups. Under the same dose regimen there was no significant difference between the two groups,However the serum concentration of aminophylline during steady stage was significantly higher in severe group than that in moderate group (18.64±10.383 vs 11.407±4.839;P<0.05).The non-linear kinetics of thco- phylline might serve as an explanation for this phenomenon.It ten patients, adverse reactions of theophylline,such as vomiting,sinus tachycardia,agi- tation and nervousness occurred.The side effects correlated with serum con- centration of theophylline. The data showed that the aminophylline regimen used here appeared to be correct.Both intensified clinical observation and serum drug monitoring are important to avoid severe toxic effects due to overdose,especially in severe cases.
出处
《医学研究生学报》
CAS
1992年第2期106-108,182-183,共5页
Journal of Medical Postgraduates
