摘要
小鼠感染血吸虫尾蚴后第7d,1次灌服对硝基苯甲酰还原青蒿素300mg/kg。结果表明:给药后4h童虫皮层即有变化,8h已十分明显。主要表现为表皮水肿,皮层褶嵴融合,形成大量球状物或小泡。12h后皮层糜烂破溃剥落,并有白细胞附着于皮层损害处。从体表面积和体积的测量计算看,7～12d龄童虫生长基本停滞,而第13d又趋恢复。此结果为本药预防血吸虫病的最佳疗程的设计提供了科学依据。
The effect of 12-(p-nitrobenzoyl) dihydroartemisinine on the tegumental surface of schistosomula was studied with scanning electron microscope after administering the drug to mice infected with schistosome cercariae at a single dose of 300 mg/kg. The results showed that changes of the tegumental surface occurred 4h after medication, and became more apparent 8h after medication Major tegument changes included swelling, ridges of the tegumental surface became closer and even fused with each other and formed numerous ball like materials or bulbs. Erosion, disruption, peeling and the attachment of the host leukocyts to damaged areas of the tegument were observed 12h after treatment. The area and volume of the worms both in experimental and control groups were determined. The results showed that the growth of schistosomula stopped on 7-12d, but it developed slightly on 13d in the experimental group. This finding provided scientific evidence on proposal for the best course of treatment with this drug.
出处
《中国血吸虫病防治杂志》
CAS
CSCD
1992年第5期267-269,321,共4页
Chinese Journal of Schistosomiasis Control
关键词
对硝基苯甲酰还原青蒿素
日本血吸虫童虫
扫描电镜
12-(P-Nitrobenzoyl) dihydroartemisinine, schitosomulum japonica, scanning electron microscope
