摘要
1次sc10％的干啤酒酵母混悬液0.2ml/10g。5天后小鼠的开阔行为活动 减少,被动学习过程中错误数增加,脾脏肿大,耐缺氧能力减弱。15天后皮层M受 体数减少,纹状体M受体数增加。中药党参及脑复康均能改善sc酵母引起的学习障 碍。本结果初步表明,sc酵母可以作为某种适合于中医药实验研究的虚证动物模型。
After 5 days a single subtutaneous injection(sc) of 0.2ml/10g of a 10% suspension of dried brewers' yeast in 0.9% NaCl, the mice appeared learning impairment sust- ained for at least 25 days in step-down and step-through tasks. Codonopsis Pilosulae and piracetam improved the amnesia caused by sc yeast.A decrease in activity of open filed was observed in mice received yeast frem 5 to 10 days after sc. A low ability of tolerence to hypoxia and hypersplenotrophy were also observed in yeast-injected mice. Receptor binding assay showed that 15 days following sc yeast the muscarinic receptors were decreased in cortex, howerer, increased in striatum. These experimental data indicated that sc yeast might be a Deficiency Sydrome Mcdel for studying the effects of Chinese Materia Medica.
出处
《中药药理与临床》
CAS
CSCD
1992年第2期41-44,共4页
Pharmacology and Clinics of Chinese Materia Medica
关键词
虚证模型
啤酒酵母
学习记忆
毒蕈碱受体
党参
脑复康
Deficiency: Syndrome Model
Brewers'yeast
Learning and Memory
Muscarinic receptors
Codpnppsis Pilosulae
Piracetam
