摘要
对100例汉族正常无血缘关系的个体和按WHO糖尿病诊断标准确诊的54名汉族胰岛素依赖型糖尿病(IDDM)患者,采用非放射性同位素地高辛标记的DR_3基因碱基序列特异性寡核苷酸探针(DRB10301,0302),进行斑点杂交(Dot,blot)。结果显示正常对照组DR_3基因(DRB10301)携带者为6%,而IDDM病人高达53.6%(P<0.001,RR=18.17)。
unrelated normal control and 54 IDDM patients of Chinese Han nationality were examined for HLA-DR3 by serological and DNA typing using PCR-SSO analysis.The results showed that there were 6% DR3 gene(DRB1 0301) carriers in the normal controls while 53.6% in IDDM patients(P<0.001)
出处
《中国糖尿病杂志》
CAS
CSCD
1994年第1期8-10,共3页
Chinese Journal of Diabetes