摘要
本文介绍了青蒿琥酯早期治疗预防动物血吸虫病的疗效.实验动物于感染血吸虫尾蚴后第7d开始喂服青蒿琥酯,剂量分别为小鼠300mg/kg,兔20—40mg/kg及犬30mg/kg,每wk 1次,服用4—6次,对小鼠、兔和犬的减虫率分别为77.50%—90.66%、99.53%和97.10%.青蒿琥酯能杀灭宿主体内尚未发育成熟的血吸虫,可保护肝脏免受血吸虫及其虫卵的危害.并适用于不同感染度及反复感染的实验动物.在几种青蒿素衍生物中,采用同剂量、同疗程青蒿琥酯杀童虫作用优于蒿甲醚和还原青蒿素.
Experimental animals were treated with artesunate after infected with Schistosoma japonicum cercariae for 7d. The dosage was 300 mg/kg for mice,20-40 mg/kg for rabbits and 30 mg/kg for dogs once a wk for 4-6 wk by oral administration. The results showed that the worm reduction rates were 77. 50%-90. 66%, 99. 53% and 97.10% respectively. Artesunate could kill S.japonicum in the immature stage within the host body, therefore, the hazard of liver damage caused by worms and their eggs could be avoided. Artesunate was appropriate to treat animals with different intensity of infection and repeated infections. In the comparative studies, many derivatives of artemisinin were used at the same dosage and course, the results indicated that artesunate was more effective than artemether or dihy-roartemisinin in killing schistosomulum.
出处
《中国血吸虫病防治杂志》
CAS
CSCD
1995年第3期129-133,共5页
Chinese Journal of Schistosomiasis Control
基金
"八五"国家科技攻关项目
