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充血性心力衰竭患者心钠素内皮素与内源性洋地黄样物质的变化

Changes of atrial natriuretic factor, endothelin and endogenous digitalislike levels in patients with congestive heart failure
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摘要 用放免法测定46例充血性心力衰竭患者的血浆心钠素与内皮素水平,以及其中30例患者的血清内源性洋地黄样物质浓度,发现三者呈正相关(P<0.05),且随心衰加重而上升。①心钠素:心功能Ⅳ级(244.2±123.6)(x±s,pg/m,下同)与Ⅰ级(89.1±30.5)、Ⅱ级(109.7±18.2)、Ⅲ(137.1±57.7)相比有显著差异(P<0.01~0.05),Ⅲ级比Ⅰ级上升显著(P<0.05)。②内皮素:Ⅳ级(73.0±25.9)与Ⅰ级(37.0±11.2)、Ⅱ级(41.4±7.2)相比上升非常显著(P<0.01),Ⅲ级(53.5±17.5)比Ⅰ级更高(P<0.05)。③内源性洋地黄样物质:Ⅳ级(227.4±107.2)与Ⅰ级(119.4±30.4)、Ⅱ(122.7±24.3)相比上升显著(P<0.05)。 The plasma atrial natriuretic factor(ANF) and endothelin(ET) levels of 46 patients with congestive heart failure and serum endogenous digitalislike substancet(EDLS) of 30 cases were detected by radioimmunoassay. It was found that ANF,ET and EDLS are positively correlated with each other and increasd with heart failure developing. 1.ANF: There is significant difference between cardiac function class Ⅳ(244. 2±123. 6, x±s pg/ml, hereinafter same) and class Ⅰ(89. 1±30.45), claes Ⅱ(109. 7±18. 2), class Ⅲ (137. 1±57. 5, P<0.01-0.05); it is markedly higher in class Ⅲ than class Ⅰ(P<0.05). 2. ET: It increases significantly in class Ⅳ(73.0 ±25.9) compared with class Ⅰ(37.0±11.2) and claas Ⅱ (41.4 ±7.2, P<0.01); and higher in class Ⅲ( 53.5±17.5) than class Ⅰ(P<0. 05).3. EDLS: It rises markedly in class Ⅳ(227. 4±107. 2) than class Ⅰ(119. 4±30. 4) and classⅡ(122.7±24.3, P<0.05) .
机构地区 宁波市第二医院
出处 《现代实用医学》 1995年第3期108-109,150,共3页 Modern Practical Medicine
关键词 心力衰竭.充血 心钠素 内皮素 内源性洋地黄样物质 Heart failure Congestive Digitalis Endotheliotoxin
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