摘要
目的 :评价熊去氧胆酸 (UDCA)治疗妊娠期肝内胆汁淤积症 (ICP)的效果。方法 :3 8例患者 ,随机分成两组。治疗组 17例 ,采用UDCA 10 0mg ,po ,tid。对照组 2 1例 ,给予 10 %葡萄糖注射液 5 0 0mL ,维生素C 3g ,肌苷 0 .4g ,静脉滴注 ,两组均以 14d为 1个疗程 ,观察疗效。结果 :治疗组瘙痒评分治疗 1周后明显下降 ,血丙氨酸氨基转移酶 (ALT)和血清总胆汁酸 (TBA)明显下降 (P <0 .0 5 ) ,而对照组无明显改变 (P >0 .0 5 ) ;与对照组相比 ,治疗组早产、胎儿窒息、羊水粪染发生明显减少 (P <0 .0 5 )。结论 :UDCA是治疗ICP安全。
Objective:To observe the effect of ursodeoxycholic acid (UDCA) in treatment of intraheptic cholestasis patients during pregnancy. Methods:Thirty-eight suitable patients were randomised into two groups. The treatment group(n=17) took UDCA 100 mg, po, tid; the control group(n=21) received 10% glucose injection with VitC and inosine, iv, gtt. Both group were observed for 14 d. Results:One week later, itching scores, and plasma ALT and TBA, as well as occurrences of fetal distress, preterm labour and meconium staining in amniotic fluid in the treatment group were lowered significantly than in the control group (P<0.05). Conclusion:UDCA is a safe, effective drug in the treatment of intraheptic cholestasis patients during pregnancy.
出处
《医药导报》
CAS
2004年第7期454-456,共3页
Herald of Medicine
关键词
熊去氧胆酸
胆汁淤积/妊娠
Ursodeoxycholic acid
Intrahepatic cholestasis/pregnancy
