摘要
采用免疫组织化学技术定位检测了19例晚期血吸虫病（晚血）患者脾脏内T细胞亚群。发现晚血患者脾脏动脉周围淋巴鞘和边缘区的CD4+T细胞（辅助性／诱导性T细胞）百分比和CD4+／CD8+（抑制性／细胞毒T细胞）比值显著降低，CD8+T细胞百分比明显增高，而且由于脾脏纤维化，导致红索区T细胞稀疏、动脉周围淋巴鞘T细胞外移。提示晚血患者脾脏内T细胞亚群的改变可能在晚血的免疫调控中起重要作用。
The T cell subsets in the spleen of l9 patients with advanced schistosomiasis Japonica were detected with immunohistochemical technique.It was found that both CD4+T cells in lymphocyte sheath and marginal zone of spleen artery and ratio of CD4 +/CD8+ T cells decreased obviously, while the percentage of CD8+ T cells increased obviously. Because of the spleen fibrosis formed,the T cells in red rnedulla were scarce. The T cells of lymphocyte sheath located in artery moved outside. It suggested that change of T cell subsets in spleen of advanced schistosomlasis japonica may play an important role in immune regulation.
出处
《中华疾病控制杂志》
CAS
1997年第2期99-100,共2页
Chinese Journal of Disease Control & Prevention
关键词
晚期血吸虫病
脾脏
T细胞亚群
advanced schistosomiasis japonica
spleen
T cell subsets
