摘要
①目的探讨卵巢囊腺癌细胞核ＤＮＡ的含量及临床意义。②方法应用图像分析技术，对５６例卵巢囊腺癌ＤＮＡ含量进行了原位定量测定分析。③结果卵巢囊腺癌ＤＮＡ含量二倍体／近二倍体（Ｄ／ＮＤ）者９例（１６．１％），ＤＮＡ含量异倍体（ＡＮ）者４７例（８３．９％）。ＡＮ卵巢囊腺癌的淋巴结转移率明显高于Ｄ／ＮＤ（χ２＝１１．４１，Ｐ＜０．０１）。６６．７％的Ｄ／ＮＤ卵巢囊腺癌瘤体直径≤５ｃｍ，而７５％的ＡＮ卵巢囊腺癌瘤体直径＞５ｃｍ（χ２＝５．８６，Ｐ＜０．０５），提示卵巢囊腺癌直径５ｃｍ时，可能是其生物学特性发生转变的重要时期。④结论卵巢囊腺癌细胞核ＤＮＡ含量的测定，对指导临床诊断和估计预后有较大的实用价值。
Objective To study the level and clinical significance of DNA polidy in ovarian cystadenocarcinoma. Methods Nuclear DNA content were quantitatively determined in situ by image analysis technology in 56 cases of ovarian cystadenocarcinoma. Results There were 9 cases with D/ND pattern and 47 cases with AN pattern. The lymphatic metastasis rate with AN patterm was significantly higher than that of D/ND pattern ( χ 2=11.41,P<0.01). 66.7% cases with D/ND pattern had their tumor diameter<5cm, 75% of AN pattern patient had larger tumors(diameter>5cm)( χ 2=5.86,P<0.05 ). The tumor diameter of 5 centimeter might be an important point in refelcting the biological behavior. Conclusion Nuclear DNA content of ovarian cystadenocarcinoma is of practical value in diagnosis, prognosis and choice of treatment.
出处
《齐鲁医学杂志》
1998年第2期17-18,共2页
Medical Journal of Qilu
关键词
卵巢肿瘤
囊腺癌
DNA
图像处理.计算机辅助
ovarian neoplasms
cystadenocarcinoma
DNA
image processing, computer assisted
