摘要
山麦冬总皂甙20mg/kg iv 能明显降低 MAP(P<0.01)、HR(P<0.01)、左室内压(LVP,P<0.01)以及左室内压最大变化速率(dp/dt_(max),P<0.01),使 MVO_2I 显著减少(P<0.01),同时 CO 及左室做功指数(LVWI)也明显降低。山麦冬总皂甙对 TPVR 和左室舒张末压(LVEDP)无明显影响。结果提示,山麦冬总皂甙对心肌有抑制作用,能明显降低心肌耗氧量。
The effects of total saponins of liriope spicata lour(TSLSL)on hemodynamics in anesthetized cats were studied.The results showed that TSLSL(20mg/kg iv)lowered the blood pressure(BP),LVP,dp/dt_(max) and HR.The MVO_2I was greatly decreased(P<0.01),while the CO was also reduced(P<0.05).LVEDP and TPVR were not altered.These results suggested that the lowering of myocardiac oxygen consumption mainly due to TSLSL's inhibition of cardiac contractivity.
关键词
心肌耗氧量
血液动力学
麦冬
皂甙
total saponins of liriope spicata lour(TSLSL)
hemodynamics
myocardiac oxygen consumption
