摘要
目的：观察不同种类抗生素作用于细菌后诱导释放内毒素的情况。方法：选择临床上常用的七种抗生素，体外作用于大肠杆菌Ｖ５１７，检测培养上清液内毒素水平和细菌形态学改变。结果：不同种类抗生素作用于大肠杆菌Ｖ５１７后，在抑制、杀灭细菌，引起细菌形态学改变的同时，能不同程度诱导细菌释放一定量的内毒素；其中头孢氨噻肟，头孢他啶，哌拉西林和环丙沙星诱导释放的内毒素较多，伊米配能和头孢哌酮诱导释放的内毒素较少。结论：不同种类抗生素具有诱导大肠杆菌释放内毒素的能力。
Objective: To evaluate the release of endotoxin
from gramnegative bacterium after incubated with different antibiotics. Methods: We measured
the endotoxin level of E coli V517 exposed to the seven antibiotics frequently used in clinical.
Results: The study shows that Cefotaxime,Ceftazidime, piperacillin and Ciprofloxacin induced
the highest release of endotoxin, whereas Imipenem and Cefoperazone induced the lowest
release of endotoxin. Conclusion: The endotoxin levels and the rate of release of endotoxin
vary with the antibiotics used and is not necessarily correlated with the rate of bacterial killing.
出处
《中国民康医学》
1999年第4期28-31,65,共5页
Medical Journal of Chinese People’s Health
关键词
内毒素
抗生素
细菌
EndotoxinAntibiotticBacterium
