摘要
目的:研究糖尿病患者血浆纤维蛋白原水平与功能。方法:用蕲蛇酶(Acutulase)水解纤维蛋白,用计算机自动检测系统测定。结果:1.无并发症糖尿病病人20例,FMPV:0.579 ± 0.130,Amax:0.297±0.060,S:3.100±0.850(g/L),FMPV/Amax:1.957±0.17O,DT:15±5 s;2.有并发症(高血压、糖尿病性肾病等)糖尿病病人20例,FMPV:0.847±0.190,AmaX:0.406± 0.090,S:4.970 ±0.950(g/L),FMP/Amax:2.067±0.190,DT:9±3 s。结论:糖尿病患者的纤维蛋白原水平与功能高于健康成人,有并发症者尤甚,表明糖尿病患者存在高凝状态,纤维蛋白原水平增高与功能亢进为并发血管病变及血栓形成的重要因素。
Objective:Study of plasma fibrinogen (Fbg) level and function in patients with diabetes mellitus. Method: Acutulase hydrolyzod Fbg and celculator automatic detection system were used for defection.Results: 1. Diabetes mellitus 20 cases no complications, FMPV (fibrin monomer polymerization reaction speed) was 0. 567 ± 0.130, Amax (maximum affraction luminosity) was 0.297 ± 0.060, S (fibrinogen concentration) was 3.100± 0.850 (g/L) , FMPV/Amax was 1.957±0.170, DT(reaction delayed time) was 15 ± 5 s. 2. Diabetes mellitus 20 cases with complications ( hypertension, diabetes nephrosil etc) FMPV: 0.847 ±0.190, A-max: 0.406 ±0.090, S:4.970± 0.950 (g/L), FMPV/Amax: 2.067 ±0.190, DT: 9±3 s. Conclusion: The patients with diabetes mellitus Fbg level and function were significatly highter than healthy adults groaps, diabetes mellitus with complications were augment sensible. This study showed that the patients with diabetes mellitus were bypercoagulation and increased of Fbg level and function is play a importance cause for complication on vaso - lesion and thrombosis.
出处
《血栓与止血学》
1999年第3期101-103,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
纤维蛋白原
糖尿病
fibrinogen Diabetes mellitus
