摘要
目的：评价血浆降钙素基因相关肽（ＣＧＲＰ）含量与肺循环血流动力学、心房纤颤（简称房颤）之间关系及经皮球囊二尖瓣成形术（ＰＢＭＶ）对ＣＧＲＰ含量的影响。 方法：２８ 例风湿性二尖瓣狭窄行ＰＢＭＶ 的患者，按有无房颤分为窦性心律组（Ａ组， １４ 例）和房颤组（Ｂ组， １４例）。利用ＰＢＭＶ前后心导管和超声心动图检查，测量平均肺动脉压（ＭＰＡＰ），平均左房压（ＭＬＡＰ），左房内径（ＬＡＤ）和瓣口面积（ＭＶＡ）。ＰＢＭＶ前、后即刻和１ 周分别抽血测血浆ＣＧＲＰ含量。 结果：ＰＢＭＶ前、后两组患者血浆ＣＧＲＰ含量差异不显著，ＰＢＭＶ后两组患者血浆ＣＧＲＰ明显升高；相关分析表明，ＣＧＲＰ含量与ＭＰＡＰ、ＭＬＡＰ、心功能指数呈负相关。 结论：ＣＧＲＰ含量不足可能参与二尖瓣狭窄的肺循环血流动力学的病理生理改变及心功能不全的发病过程。
Objectives:To Study the effects of percutaneous balloon mitral valvuloplosty (PBMV) on the plasma levels of calcitonin gene related peptide (CGRP) and the relationship between the levels of plasma CGRP and the hemodynamics of pulmonary circulation atrial fibrillation in patients with rheumatic mitral stenosis. Methods: 28 patients with rheumatic mitral stenosis were divided into two groups: group A 14 patients with sinus rhythm, group B, 14 patients with chronic atrial fibrillation. The PBMV was performed in all cases and the following indexes were measured: mean pulmonary arterial pressure (MPAP), mean left atrial pressure (MLAP). Left atrial diameter (LAD) and mitral valve area (MVA), the plasma levels of CGRP before and after PBMV. Results: There were no difference between two groups in the plasma levels of CGRP ( P >0.05). The CGRP level was significanct higher after PBMVthan before PBMV. There was negative correlation between the plasma level of CGRP and MPAP、MLAP、cardiac function index. Conclusions: CGRP may play an importemt role in the pathophysiological process of mitral stenosis.
出处
《医学研究生学报》
CAS
1999年第S1期30-32,共3页
Journal of Medical Postgraduates
关键词
二尖瓣狭窄
经皮球囊二尖瓣成形术
降钙素基因相关肽
Mitral valve stenosis
Percutaneous balloon mitral valvuloplasty
Calcitonin gene related piptide
