摘要
目的研究急性心理应激对不同焦虑特质人格新兵的免疫功能及其应激反应程度的影响。方法:以“状态-特质焦虑 问卷(STAI)”将某部新兵分成高、低焦虑组,每组各16人。用红细胞免疫黏附酵母菌功能测定方法(郭氏法)和双色免疫荧光 法流式细胞仪测定被试者基础期(新兵打靶考核前4d)、应激期(打靶考核当时)、恢复期(打靶后5d)的红细胞C3b受体花环 率(RBC-C3bRR)及CD4+、CD8+定量。结果:(1)高、低焦虑组被试者的RBC-C3bRR基础期与应激期及恢复期呈显著性差异 (P<0.01或P<0.05),应激期与恢复期差异不显著;高焦虑组3个时期的RBC-C3bRR均低于低焦虑组,尤以恢复期2组间 差异显著(P<0.05)。(2)高焦虑组被试者3个时期的CD4+定量、CD4+/CD8+比值均低于低焦虑组,CD8+定量高于低焦虑 组;高焦虑组被试者应激期CD4+显著下降(P<0.05)、CD4+/CD8+比值与恢复期有显著差异(P<0.01),而低焦虑组仅应激 期CD4+定量与恢复期有显著差异(P<0.01)。结论:(1)由打靶考核引起的心理应激对新兵红、白细胞免疫功能均有影响,但 对其红细胞天然免疫黏附功能影响的持续时间更长;(2)焦虑人格特质是急性心理应激致个体免疫功能改变的影响因素之 一,心理应激对高焦虑特质个体的影响强于低焦虑特质个体。
Objective:To study the immune function in recruits with different trait-anxiety levels under acute military psychological stress.Methods:Through group psychological test(the state-trait anxiety inventory),the subjects were divided into high trait-anxiety group and low trait-anxiety group(n=16).RBC-C 3 bRR(RBC-C 3 b receptors rate),CD4 + and CD8 + were measured by Rosette of RBC-C 3 b method and flow cytometric analysis before,during and after acute psychological stress (military examination).Results:(1)The RBC-C 3 bRR in high trait-anxiety group was less than in low trait-anxiety group in 3different periods,with significant difference existing after acute psychological stress(P<0.05).(2)CD4 + and CD4 + /CD8 + of3periods in high trait-anxiety group were lower than those of the low trait-anxiety group,while CD8 + was higher than that of lower trait-anxiety group;CD4 + during acute stress in high trait-anxiety group decreased significantly (P<0.05), and there was significant difference in CD4 + /CD8 + between during stress and the recovery period.In the low trait-anxiety group, only CD4 + had significant difference between during stress and the recovery period(P<0.01).Conclusion:(1)Acute psycho-logical stress induced by military examination can affect both WBC and RBC immune function in recruits,with the effect on RBC immune function stronger than that on WBC immune.(2)The differences in immune index changes between high trait-anxiety and low trait-anxiety group suggest that personality can affect the immune function,which may explain why some people are more sensitive to psychosomatic disorder after stress. [
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2004年第6期590-593,共4页
Academic Journal of Second Military Medical University
基金
全军医药卫生科研"十五"规划指令性课题(01Z059)
第二军医大学军事医学研究课题(2001J-2).
