摘要
Objective To study the relationship between isometric exercise and myocardial ischemia in patients with coronary artery disease (CAD) Methods Twenty CAD patients and 10 normal subjects were included in our study All subjects performed maximal brief isometric exercise (BIE), maximal sustained isometric exercise (SIE) and dynamic exercise (DE) Hemodynamic parameters and cardiac function were measured by Echo Doppler technique To avoid influence of different baseline values, increment (Δ%) of exercise response was used as parameter for significant analysis: Δ%=(exercise values-baseline values)/baseline values×100% Results Positive exercise testing (PET) showed no evidence of myocardial ischemia during BIE and SIE even though their rates of perceived exertion (RPE) were similar to DE Δ% heart rate (HR) and Δ% rate pressure product (RPP) were higher during DE than during SIE and BIE in negative exercise testing (NET) and normal controls (NOR) ( P <0 01), except PET during DE and SIE; Δ% systolic blood pressure (SBP) was higher during DE than during BIE in NOR ( P <0 01) Δ% SBP in NOR and NET during SIE was higher than during BIE ( P <0 05) Δ% diastolic blood pressure (DBP) was the highest during SIE among exercises in all groups ( P <0 05) There were no significant inter group differences of Δ% HR, Δ% SBP, Δ% DBP and Δ% RPP during SIE, BIE and DE, except that Δ% SBP during SIE was higher in NET than in NOR and PET ( P <0 05) In NOR, Δ% ejection fraction (EF), Δ% fractional shortening of the minor semi axis (SF), Δ% cardiac output (CO), Δ% E/A was higher during DE than during SIE and BIE ( P <0 01) Δ% stroke volume (SV) was similar during DE, SIE and BIE There were no significant differences in Δ% EF, Δ% SF, Δ% CO, Δ% SV and Δ% E/A during DE, SIE and BIE in both NET and PET, except lower Δ% CO in NET during SIE and BIE than DE ( P <0 01) There were no inter group differences in Δ% EF, Δ% SF, Δ% CO and Δ% E/A, except th
Objective To study the relationship between isometric exercise and myocardial ischemia in patients with coronary artery disease (CAD) Methods Twenty CAD patients and 10 normal subjects were included in our study All subjects performed maximal brief isometric exercise (BIE), maximal sustained isometric exercise (SIE) and dynamic exercise (DE) Hemodynamic parameters and cardiac function were measured by Echo Doppler technique To avoid influence of different baseline values, increment (Δ%) of exercise response was used as parameter for significant analysis: Δ%=(exercise values-baseline values)/baseline values×100% Results Positive exercise testing (PET) showed no evidence of myocardial ischemia during BIE and SIE even though their rates of perceived exertion (RPE) were similar to DE Δ% heart rate (HR) and Δ% rate pressure product (RPP) were higher during DE than during SIE and BIE in negative exercise testing (NET) and normal controls (NOR) ( P <0 01), except PET during DE and SIE; Δ% systolic blood pressure (SBP) was higher during DE than during BIE in NOR ( P <0 01) Δ% SBP in NOR and NET during SIE was higher than during BIE ( P <0 05) Δ% diastolic blood pressure (DBP) was the highest during SIE among exercises in all groups ( P <0 05) There were no significant inter group differences of Δ% HR, Δ% SBP, Δ% DBP and Δ% RPP during SIE, BIE and DE, except that Δ% SBP during SIE was higher in NET than in NOR and PET ( P <0 05) In NOR, Δ% ejection fraction (EF), Δ% fractional shortening of the minor semi axis (SF), Δ% cardiac output (CO), Δ% E/A was higher during DE than during SIE and BIE ( P <0 01) Δ% stroke volume (SV) was similar during DE, SIE and BIE There were no significant differences in Δ% EF, Δ% SF, Δ% CO, Δ% SV and Δ% E/A during DE, SIE and BIE in both NET and PET, except lower Δ% CO in NET during SIE and BIE than DE ( P <0 01) There were no inter group differences in Δ% EF, Δ% SF, Δ% CO and Δ% E/A, except th
基金
ThisstudywassupportedbytheNaturalScienceFundofJiangsuProvince!(NoBK95082311)
