摘要
目的 探讨黄芪注射液治疗小儿病毒性心肌炎的疗效及机理。方法 72例病毒性心肌炎患儿随机分为两组:36例给予黄芪治疗(黄芪组),36例给予维生素C治疗(VitC组)。观察临床疗效及治疗前后血浆超氧化物歧化酶(SOD)、脂质过氧化物(LPO)及T细胞亚群的变化。结果 病毒性心肌炎患儿血SOD下降(P<0.01),LPO上升(P<0.01);CD4^+及CD4^+/CD8^+均下降(P<0.01),CD8^+上升(P<0.01)。黄芪能明显提高血浆SOD活性,降低LPO水平,用药后使患儿CD4^+、CD8^+及CD4^+/CD8^+比值趋于正常。结论 黄芪注射液具有治疗病毒性心肌炎的作用,提高SOD活性、降低LPO水平、调节细胞免疫功能是其取得疗效的机理之一。
Objective To explore the therapeutic effect and its mechanism of Astragalus Membranacous(AM)in treating children with viral myocarditis. Methods 72 cases were randomly divided into two groups. 36 cases treated with AM(AM group)and the others treated with Vitamin C(VitC group). The clinical effectiveness and the changes of superoxide dismutase (SOD),lipid pexoxide(LPO),and T-cell subgroup were observed before and after treatment. Results Concentration of serum SOD,the level of CD4+and the ratio of CD4+/CD8+ were decreased(P<0. 01),concentration of serum LPO and the level of CD8+ were increased in children with viral myocarditis(P<0. 01). AM markedly increased the activity of SOD,reduced the level of LPO,enabled the level of CD4+ ,CD8+and the ratio of CD4+/CD8+ tended to normalize. There were no differences in the cure rate and mean course of therapy both groups (P>0. 05). Conclusion AM played an impo tant role in the treatment of viral myocarditis with the mechanism of increasing the activity of SOD,reducing the level of LPO and modulating celluar immune function.
出处
《青岛医药卫生》
2001年第6期401-402,共2页
Qingdao Medical Journal
关键词
黄芪
病毒性心肌炎
超氧化物歧化酶
脂质过氧化物
T细胞亚群
Astragalus membranacous Viral myocarditis Superoxide dismutase Lipid pexoxide T-lymphocyte subset
