摘要
目的 探讨将微量肝素应用于术后早期病人预防高粘滞血症。方法 3 0例病人术后随机分为 15mg肝素组和 10 0mg肝素组 ,每组 15例 ,均在术后 1h应用肝素。 15mg肝素组 :肝素 5mg +5 %葡萄糖液 5 0 0ml静脉滴注 ,3次 /日。 10 0mg肝素组 :肝素 5 0mg皮下注射 ,2次 /日。两组病人在用药前及用药后 3～ 4h内分别采静脉血测定血液粘度 ,并观察用药后手术切口渗血情况。结果 15mg肝素组全血粘度、全血还原粘度和血浆粘度明显降低 ,较用药前有非常显著变化 ,无一例患者手术切口渗血。 10 0mg肝素组各项指标较用药前无明显改变 ,9例患者出现切口渗血。结论 术后早期应用微量肝素静脉滴注降低病人血液粘度的效果显著 ,该剂量不会引起手术切口渗血 ,是防治术后早期静脉血栓形成安全、有效、简便的方法之一。
Objective To prevent blood hyperviscosity of early postoperative period by using microdose heparin and comparison with the effect of traditional dose of heparin.Methods 30 patients were randomly divided into two groups,that is 15 cases in Heparin groupⅠand 15 cases in Heparin groupⅡ.Heparin was administered at 1st hour after operation.In heparin groupⅠ,5 mg heparin dissolved in 5% 500 ml glucose solution was used intravenously three times per day.In heparin groupⅡ,50 mg heparin was injected subcutaneously two times per day.The venous blood viscosity was measured and wound bleeding was observed before and 3-4 hour after heparin adminisfration.Results Whole blood viscosity,whole blood reduction viscosity and plasma viscosity in Heparin groupⅠ decreased significantly after use of heparin (P<0.01).Wound blooding did not increase in cases of this group.Whole blood viscosity.Whole blood reduction viscosity and plasma viscosity of Heparin groupⅡ did not change after heparin injection(P>0.05).In 9 cases wound blooding was observed in this group.Conclusions Microdose heparin could decrease blood viscosity significantly and not cause incision bleeding.This is a simple,safe and effective method to prevent venous thrombosis in early postoperative period.
出处
《临床外科杂志》
2003年第S1期9-11,共3页
Journal of Clinical Surgery
基金
四川省教育厅资助项目 (97- 1 33)
关键词
术后早期
微量肝素
高粘滞血症
预防
early postoperative period
microdose heparin
blood hyperviscosity
prevention
