摘要
目的 探讨一氧化氮(NO)与胎儿宫内窘迫的关系。方法 用格瑞氏法和硝酸酶还原法对40例正常妊娠孕妇(对照组)及23例胎窘孕妇(胎窘组)血及脐血中NO代谢产物亚硝酸基/硝酸基(NO2-/NO3-)进行测定。结果 胎窘组母血和脐血NO2-/NO3水平显著低与对照组(P<0.01);脐血NO2/NO3水平与pH、PO2显著正相关,与PCO2显著负相关(P<0.01)。结论 胎儿宫内窘迫的发生发展与NO的减少密切相关。
Objective:To study the relationship between serum nitric oxide (NO)level and fetal distress. Methods:23 patients with fetal distress( fetal distress group)and 40 normal late trimester pregnanct women(control group)were studied. Serum NO2-/NO3-, the endproducts of NO were measured with the Griess reaction after reduction with nitrate reductase. Results:The mean NO2-/NO3- in maternal venous serum were 30.28 ± 5.46μmol/L in control group and 18.39±2.34μmol/L in fetal distress group, Umbilical serum NO2-/NO3- were 13.46±4.82μmol/L in control group and 7.98± 3.06μmol/L in fetal distress group . Maternal serum NO2- /NO3- in fetal distress group decreased significantly when compared with the control group (P < 0.01), while significantly lower serum NO2-/NO3- were also found in umbilical venous blood in fetal distress group (P < 0.01). There was a positive correlation between pH, PCO2 and umbilical serum NO2- /NO3- levels (P < 0.01). Conclusion: The fetal distress was associated with the decrease of NO; The change of NO level may play an important role in the pathophysiological changes in fetal distress.
出处
《中国优生与遗传杂志》
2003年第S1期26-27,共2页
Chinese Journal of Birth Health & Heredity
关键词
胎儿窘迫
一氧化氮
Fetal distress
Nitric oxide
