摘要
充血性心力衰竭常合并心脏电活动同步异常,它们在某种程度上会引起或加重心脏的机械收缩异常。再同步化治疗心力衰竭被认为是严重心衰合并心电学异常病人的一种理想的非药物辅助治疗。临床研究已经证实再同步化治疗严重充血性心力衰竭可以改善心功能,提高生活质量。其可能机制包括心脏整体活动的再同步化、逆转心脏重塑、抗心律失常等。本文综述了心脏失同步化的病理生理及心脏再同步化治疗方法及临床试验、适应症和存在的问题。
Patient with congestive heart failure was always complicated by cardiac electrophysiological asynchrony,which had been demonstrated to contribute to or strengthen cardiac contraction asynchrony.Cardiac resynchronization therapy had been suggested as an ideal non-pharmacological supplementary therapy strategy in patients with severe heart failure and disordered electrophysiology.More and more clinical trails had confirmed that cardiac resynchronization therapy could significantly improve the functional status of NYHA and quality of life.The potential mechanisms of cardiac resynchronization therapy consist of cardiac integral contraction resynchronization,ventricular remodeling reversion and anti-arrhythmia,et al.This article reviews the pathophysiological change of cardiac dyssynchrony and the method,indication,clinical trials,unsolved issues in cardiac resynchronization therapy.
出处
《内蒙古医科大学学报》
2008年第S2期136-140,共5页
Journal of Inner Mongolia Medical University
关键词
充血性心力衰竭
心脏再同步化治疗
Congestive Heart Failure
Cardiac Resynchronization Therapy
