摘要
mdm2(murine double minute 2)最初是在自发转化的成纤维细胞中发现的,后在人体正常组织器官中观察到其表达.该基因编码一种锌指蛋白,可与P53蛋白结合,抑制p53介导的转录活性和阻止p53诱导凋亡的作用,引起肿瘤发生.人体许多肿瘤中都存在mdm2基因的扩增表达,且表达程度往往与肿瘤的临床分级、病理分期、是否转移有关.目前已证实mdm2基因启动区第309位等位基因的单核苷酸多态性(MDM2 SNP309)使许多肿瘤加速恶化.研究结果表明部分肿瘤的疗效与mdm2蛋白的表达程度有关.对近年来有关mdm2基因在肿瘤中的研究作一综述,探讨其与肿瘤的生物学行为、预后、治疗的关系.
Mdm2 (murine double minute 2) was found in fibroblasts with spontaneous transformation initially.After that its expression was detected in human normal tissue or organ.Zinc finger protein encoded by MDM2 gene can combine with P53 protein, which inhibit P53- mediated transcription activity and arrest P53- induced cell apoptosis,then cause carcinoma.Mdm2 gene expression is amplified in many human tumors, and its amplifying degree is associated with clinical scale,pathological stage and metastasis.Presently,a single nucleotide polymorphism in the promoter of the MDM2 gene,SNP309,is confirmed to increase malignance of many cases of neoplasm.Findings indicate therapeutic effect of some malignancies is relevant to the expression degree of mdm2 protein.This article reviews the study of mdm2 gene in carcinoma,and discusses the relationship between mdm2 and tumorous biological behaviour,prognosis and treatment.
出处
《昆明医科大学学报》
CAS
2009年第S1期98-102,共5页
Journal of Kunming Medical University
