期刊文献+

microRNA与肿瘤

下载PDF
导出
摘要 microRNA(miRNA)是近年来发现的一类长度约22个核苷酸非编码小分子RNA,它通过促使靶mR-NA降解或抑制其翻译来调节靶基因的表达,与个体发育、细胞凋亡、增殖、分化以及恶性肿瘤等疾病的发生密切相关。miRNA具有与癌基因或抑癌基因相似的作用,能够为肿瘤的诊断和治疗提供新的方法。
作者 王科峰 吴斌
出处 《中国医学工程》 2011年第3期182-183,186,共3页 China Medical Engineering
  • 相关文献

参考文献24

  • 1Rinaldi A,Poretti G,Kwee I,et al.Concomitant MYC and mi-croRNA cluster miR-17-92(C13 or f25)amplification in hu-man mantle cell lymphoma. Leukemia and Lymphoma . 2007 被引量:1
  • 2Connolly E,Melegari M,Landgraf P,et al.Elevated expression ofthe miR-17-92 polycistron and miR-21 in hepadnavirus-as-sociated hepatocellular carcinoma contributes to the malignant phe-notype. American Journal of Pathology . 2008 被引量:1
  • 3Loffler D,Brocke-Heidrich K,Pfeifer G,et al.Interleukin-6dependent survival of multiplemyeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conservedenhancer. Blood . 2007 被引量:1
  • 4Calin GA,Dumitru CD,Shimizu M,et al.Frequent deletions anddown-regulation of micro- RNA genes miR15 and miR16 at 13ql4 in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America . 2002 被引量:1
  • 5Krutzfeldt J,Rajewsky N,Braich R,et al.Silencing of microRNAs in vivo with ’antagomirs’. Nature . 2005 被引量:1
  • 6Johnson SM,Grosshans H,Shingara J,et al.RAS is regulated by the let-7 microRNA family. Cell . 2005 被引量:1
  • 7Lu J,Getz G,Miska EA,et al.MicroRNA expression profiles classify human cancers. Nature . 2005 被引量:1
  • 8Cimmino A,Calin GA,Fabbri M,et al.miR-15 and miR-16 induce apoptosis by targeting BCL2. Proceedings of the National Academy of Sciences of the United States of America . 2005 被引量:1
  • 9Takamizawa J,Konishi H,Yanagisawa K,et al.Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Research . 2004 被引量:1
  • 10He L,Thomson JM,Hemann MT,et al.A microRNA polycistron as a potential human oncogene. Nature . 2005 被引量:1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部