期刊文献+

冠状动脉支架术后血MMP-9水平与预后的关系

Analysis of the effect of MMP-9 on prognosis after successful coronary stenting
下载PDF
导出
摘要 目的:探讨不稳定性心绞痛患者经皮冠状动脉介入术(PCI)后血浆MMP-9对预后的预测价值。方法:选择153例单支病变接受PCI术的不稳定性心绞痛患者,术后24h抽取静脉血化验MMP-9,观察12~25个月的严重心脏不良事件。结果:术后MMP-9升高组(n=48)的严重心脏不良事件明显高于术后MMP-9正常组(19.6%VS9.8%,P<0.05),MMP-9升高组的血脂水平、他汀类药物、植入支架枚数、球囊预扩张时间及术前hsCRP水平与MMP-9正常组比较,差异有统计学意义。结论:MMP-9的升高对PCI术后患者的预后有着重要的影响,尽早、足量的他汀类药物以及关注炎症的相关指标可使病人获益更大。 目的:探讨不稳定性心绞痛患者经皮冠状动脉介入术(PCI)后血浆MMP-9对预后的预测价值。方法:选择153例单支病变接受PCI术的不稳定性心绞痛患者,术后24h抽取静脉血化验MMP-9,观察12~25个月的严重心脏不良事件。结果:术后MMP-9升高组(n=48)的严重心脏不良事件明显高于术后MMP-9正常组(19.6%VS9.8%,P&lt;0.05),MMP-9升高组的血脂水平、他汀类药物、植入支架枚数、球囊预扩张时间及术前hsCRP水平与MMP-9正常组比较,差异有统计学意义。结论:MMP-9的升高对PCI术后患者的预后有着重要的影响,尽早、足量的他汀类药物以及关注炎症的相关指标可使病人获益更大。
出处 《心肺血管病杂志》 CAS 2010年第S1期17-20,共4页 Journal of Cardiovascular and Pulmonary Diseases
关键词 基质金属蛋白酶-9 经皮冠状动脉介入术 预后 Matrix metalloproteinase-9 Pereutaneous coronary intervention Prognosis
  • 相关文献

参考文献11

  • 1Manginas A,Bei E,Chaidaroglou A,et al.Peripheral levels of matrix metalloproteinase-9, interleukin-6, and C-reactive protein are elevated in patients with acute coronary syndromes: correlations with serum troponin I. Clinical Cardiology . 2005 被引量:1
  • 2Blankenberg S,Rupprecht HJ,Poirier O,et al.Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease. Circulation . 2003 被引量:1
  • 3Kai H,Ikeda H,Yasukawa H,et al.Peripheral blood levels of matrix metalloproteinase-2 and-9 are elevated in patients with acute coronary syndromes. Journal of the American College of Cardiology . 1998 被引量:1
  • 4Nomoto K,Oguchi S,Watanabe I,et al.Involvement of inflammation in acute coronary syndromes assessed by levels of high-sensitivity C-reactive protein, matrix metalloproteinase-9 and soluble vascular-cell adhesion molecule-1. Journal of Cardiology . 2003 被引量:1
  • 5Yamamoto D,Takai S.Pharmacological implications of MMP-9inhibition by ACE inhibitors. Current Medicinal Chemistry . 2009 被引量:1
  • 6Suleiman M,Khatib R,Agmon Y,et al.Early Inflammation and Risk of Long - Term Development of Heart Failure and Mortality in Survivors of Acute Myocardial Infarction:Predictive Role of C- Reactive Protein. Journal of the American College of Cardiology . 2006 被引量:1
  • 7Smeglin A,Frishman WH.E lastinolytic matrix metalloproteinases and their in-hibitors as therapeutic targets in atherosclerotic plaque instability. Cardiology Review . 2004 被引量:1
  • 8Dabek J,Kulach A,Gasior Z.The role of matrix metalloproteinases in acute coronary syndromes. European Journal of Internal Medicine . 2007 被引量:1
  • 9Jones GT,,Kay IP,Chu JW,et al.Elevated plasma active matrixmetalloproteinase-9 level is associated with coronary artery in-stent restenosisth. Arteriosclerosis and Thrombosis . 2006 被引量:1
  • 10PIZZI C,MANZOLI L,MANCINI S,et al.Analysis of potential predictorsof depression among coronary heart disease risk factors including heartrate variability,markers of inflammation,and endothelial function. European Heart Journal . 2008 被引量:1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部