摘要
目的探讨健康老年人肾脏CT灌注参数的变化。方法28例正常人按年龄分三组:Ⅰ组41~岁,Ⅱ组51~岁,Ⅲ组61~岁,全部采用Siemens 16层螺旋CT行双侧肾脏灌注扫描。采集数据,经后处理,获得肾脏血流灌注图像和时间?密度曲线(TDC),通过感兴趣区获得皮髓质的不同灌注参数,包括肾血流量(BF)、肾血容量(BV)、肾脏对比剂平均通过时间(MTT)和肾脏强化高峰时间(TTP)。结果61~岁组肾皮质的BF值较41~岁组及51~岁组明显减低,差异有统计学意义(P【0.05);41~岁组及51~岁组之间BF值差异无统计学意义(P】0.05);MTT值随年龄增大,有增加趋势,但差异均无统计学意义(P】0.05)。肾髓质灌注参数三组间比较,差异均无统计学意义(P】0.05),但BV和MTT值有增加趋势。结论CT灌注成像图更直观形象地显示了肾脏皮、髓质的血流灌注状况;年龄老化对肾脏血流的影响主要是皮质;为临床了解老化肾脏病理生理变化提供量化依据。
Objective To evaluate the varies of renal blood flow perfusion parameters with multi-slice spiral computed tomography in the healthy elderly.Methods Twenty-eight healthy people were divided into three groups:① 41-50 years old group;②51-60 years old group;③≥61 years old group.The renal perfusion scan was carried out with 16 row detector helical computed tomography.The data were analyzed by CT perfusion software.The perfusion picture and the time-density curve were obtained.Then the perfusion parameters were got in regions of interest.Results The BF value of renal cortex in over 61-year-old group was smaller than those of the 41 to 50-year-old and 51 to 60-year-old group.The differences were statistically significant(P<0.05).The MTT value increased with aging but there were no significant differences among three age groups(P>0.05).Though increasing trends appeared in BV and MTT values,no significant differences in the perfusion parameters of medulla were found among the three age groups.Conclusion CT perfusion imaging shows vivid change of renal cortical and medullary blood perfusion.The effects of aging on renal blood perfusion lie on renal cortex,and the BF value appears obvious decrease.CT perfusion imaging provides the quantification basis for the clinical understanding of the pathological and physiological changes of kidney.
出处
《中国病毒病杂志》
CAS
2009年第4期246-248,共3页
Chinese Journal of Viral Diseases
