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Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa 被引量:21

Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa
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摘要 Objective:To identify the hepatoprotective and in vitro antioxidant activity of Lumnitzera racemosa(L.racemosa) leaf extract.Methods:Animals in Group 1 served as vehicle control. Group 2 served as hepatotoxin(CCL_4 treated) group.Group 3 served as positive control(Silyntarin) group,and Group 4.S and ft served as(73,150 and 300 nig/kg bw p.o.)L.racemosa leaf extract treated groups.Moreover,in vitro antioxidant DPPH,hydroxyl radical scavenging activity(HRSA),NO,ferric reducing antioxidant power(FRAP),lipid hydroperoxide(LPO) and super oxide dismutase(SOD) were also analyzed for the leaf extract.Results:The levels of the serum parameters such as serum glutamic oxaloacetic transaminase(SGOT).serum glutamic pyruvic transaminase(SGPT).alkaline phosphatase(ALP),bilirubin,cholesterol(CHL).sugar and lactate dehydrogenase(LDH) were significantly increased in COL_4 treated rats when compared with the control group(P<0.05).But the L.racemosa leaf extract treated rats showed maximum reduction of SGOT[(210.16±19.63)IU/L].SGPT[(82.37±13.87) IU/L].ALP[(197.63±23.4.3)IU/L],bilurubilt[(2.13 ±0.84) mg/dL].cholesterol[(163.83± 13.63) mg/dL].sugar[(93.00±7.63) mg/dL]and LDH[(1134.00) ±285.00)IU/L]were observed with the high dose(300 mg/kg bw) of leaf extract treated rats. Histopathological scores showed that,no visible changes were observed with high dose(300 mg/ kgbw) of leaf extract treated rats except few mild necrosis.The IC_(50) values were observed as(56.37 ±4.87)μg/mL,(57.68±1.98) μg/mL,(64.15±2.90)μg/mL,(61.94±3.98)μg/mL,(94.53± 1.68) μg/mL and(69.7±2.65)μg/mL for DPPH,HRSA,NO,FRAP,LPO and SOL) radical scavenging activities, respectively.Conclusions:In conclusion,the hepatoprotective effect of the L.racemosa leaf extract might be due to the presence of phenolic groups,terpenoids and alkaloids and in vitro antioxidant properties. Objective:To identify the hepatoprotective and in vitro antioxidant activity of Lumnitzera racemosa(L.racemosa)leaf extract.Methods:Animals in Group 1 served as vehicle control,Group 2 served as liepatoloxin(CCL_4 treated)group,Group 3 served as positive control(Silyinarin)group,and Group 4,5 and 6 served as(75,150 and 300 mg/kg bw p.o.)L.raremosa leaf extract treated groups.Moreover,in vitro antioxidant DPPH,hydroxyl radical scavenging activity(HRSA),NO,ferric reducing antioxidant power(FRAP),lipid hydroperoxide(LPO)and super oxide dismutase(SOD)were also analyzed for the leaf extract.Results:The levels of the serum parameters such as serum glutamic oxaloacetic transaminase(SCOT),serum glutamic pyruvic transaminase(SGPT),alkaline phosphatase(ALP),bilirubin,cholesterol(CHL),sugar and lactate dehydrogenase(LDU)were significantly increased in CCL_4 treated rats when compared with the control group(P<0.05).But the L.racemosa leaf extract treated rats showed maximum reduction of SGOT[(210.36±19.63)IU/L],SGPT[(82.37±13.87)IU/L],ALP[(197.63±23.43)IU/L],bilurubin[(2.15±0.84)mg/dL],cholesterol[(163.83±15.63)mg/dL],sugar[(93.00±7.65)mg/dL]and LDH[(1134.00±285.00)IU/L]were observed with the high dose(300 mg/kg bw)of leaf extract treated rats.Histopathological scores showed that,no visible changes were observed with high dose(300 mg/kg bw)of leaf extract treated rats except few mild necrosis.The IC_(50)values were observed as(56.37±4.87)μg/mL,(57.68±1.98)μg/mL,(64.I5±2.90)μg/mL,(61.94±3.98)μg/mL,(94.53±1.68)μg/mL and(69.7±2.65)μg/mL for DPPH,HRSA,NO,FRAP,LPO and SOD radical scavenging activities,respectively.Conclusions:In conclusion,the hepatoprotective effect of the L.racemosa leaf extract might be due to the presence of phenolic groups,terpenoids and alkaloids and in vitro antioxidant properties.
出处 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2011年第5期348-352,共5页 亚太热带生物医学杂志(英文版)
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  • 1TUMA D J,CASEY C A.Dangerous Byproducts of Alcohol Breakdown Focus on Adducts. Alcohol Research and Health . 2003 被引量:1
  • 2Onyema OO,Farombi EO,Emerole GO,Ukoha AI,Onyeze GO.Effect of vitamin E on monosodium glutamate induced hepatoxicity and oxidative stress in rats. Indian J Bioc Biophys . 2005 被引量:1
  • 3Tsukamoto H,Lu S C.Current concepts in the pathogenesis of alcoholic liver injury. The FASEB Journal . 2001 被引量:1
  • 4Aqil F,Ahmed I,Mehmood Z.Antioxidant and free radical scavenging properties of twelve traditionally used Indian medicinal plants. Turkish Journal of Biology . 2006 被引量:2
  • 5Bos AR,Weaver R,Ross D.Characterization and quantification of the peroxidase in human neutrophils. Biochemistry and Biophysics . 1990 被引量:2
  • 6Ojiako OA,Nwanjo HU.Is Vernonia amygdalina hepatotoxic or hepatoprotective? Response from biochemical and toxicity studies in rats. Afr J Biotechnol . 2006 被引量:2
  • 7Toyin Y. Faremi,Stephen M. Suru,Michael A. Fafunso,Udoka E. Obioha.Hepatoprotective potentials of Phyllanthus amarus against ethanol-induced oxidative stress in rats[J]. Food and Chemical Toxicology . 2008 (8) 被引量:1
  • 8Suresh R.Naik,Vandana S.Panda.Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride‐induced liver injury in rodents[J]. Liver International . 2007 (3) 被引量:1
  • 9ROBERTA T.PCORREIA,PATRICKMCCUE,DHIRAJ A.VATTEM,MARGARIDA M.A.MAGALH?ES,GORETE R.MACêDO,KALIDASSHETTY.AMYLASE AND HELICOBACTER PYLORI INHIBITION BY PHENOLIC EXTRACTS OF PINEAPPLE WASTES BIOPROCESSED BY RHIZOPUS OLIGOSPORUS[J]. Journal of Food Biochemistry . 2004 (5) 被引量:1
  • 10Kaur Jasmeet,Bansal M P.Effect of vitamin E on alcohol-induced changes in oxidative stress and expression of transcription factors NFkappaB and AP-1 in mice brain cerebral hemispheres. Indian Journal of Experimental Biology . 2008 被引量:1

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