摘要
目的 研究眠尔康胶囊对改善小鼠睡眠作用的影响。 方法 将小鼠随机分为溶剂对照组和眠尔康胶囊 40、80、2 40mg/kg3个剂量组 ,分别为A、B、C组共 4个组。通过延长戊巴比妥钠诱导的小鼠睡眠时间实验 ,观察眠尔康胶囊对戊巴比妥钠睡眠时间的延长作用 ;通过戊巴比妥钠阈下剂量催眠实验 ,观察给戊巴比妥钠 30min内各组动物睡眠发生率 ;通过戊巴比妥钠睡眠潜伏期实验 ,观察眠尔康胶囊对戊巴比妥钠睡眠潜伏期的影响。 结果 眠尔康胶囊连续灌胃小鼠 30d ,B、C剂量组小鼠睡眠时间明显延长 (P <0 .0 5 ) ,且睡眠发生率明显增加 (P <0 .0 5 ) ,睡眠潜伏期明显缩短 (P <0 .0 5 )。 结论 眠尔康胶囊有明显改善小鼠睡眠的作用。
Objective To investigate the effect of Hang Tian Pai Mian Erkang capsules on the sleep improvement in mice. Methods The mice were randomly divided into 4 groups including solvent group, Hang Tian Pai Mian Erkang (HTPMEK) Capsules 40, 80, 240 mg/kgbw groups. With prolonged mice sleep time test by pentyl barbital sodium (PBS), the authours studied the prolonged effect of the capsules on PBS-induced sleeping time. With threshold dosage of barbital sodium hypnotizing tests, the sleep rate of the mice was observed after barbital sodium was administrated in 30 min. The effect of the capsules on the sleeping incubation period induced by barbital sodium was also tested. Results By administration of HTPMEK capsules for 30 d by gastric intubation, the mice sleeping time in middle and high dosage group was prolonged obviously (P<0.05), mice sleep rate was increased obviously (P<0.05), and the sleep incubation period was decreased significantly (P<0.05). Conclusion HTPMEK capsules can improve the mice sleep effectively.
出处
《总装备部医学学报》
2003年第2期99-100,共2页
Medical Journal of General Equipment Headquarters
关键词
睡眠
眠尔康胶囊
影响
Sleep improvement Hang Tian Pai Mian Erkang Capsules
