摘要
目的研究急性深静脉血栓(DVT)患者外周血中蛋白C活性,及细胞色素P4502C19(CYP2C19)基因表达情况,探讨在DVT患者中蛋白C系统与CYP2C19表达之间的关系,了解这两种遗传性因素在DVT患者发病过程中所起作用及其重要性。方法检测213例DVT患者外周血蛋白C活性及CYP2C19基因表达,掌握遗传性蛋白C缺陷症、CYP2C19基因突变对DVT发病影响及重要性。结果与126例对照组相比,骨折、外伤、其他手术史的DVT组的患者蛋白C活性原发性降低,差异具有统计学意义(P<0.05);CYP2C19基因变异型(中间代谢、慢代谢型)分布未见明显特点,差异无统计学意义。结论遗传性蛋白C缺陷对DVT发病起重要作用,CYP2C19基因对于DVT患者的治疗预后关系密切,但对于DVT发病作用未见明显特征。而蛋白C与CYP2C19基因表达在DVT患者中未见明显关联。
Objective To explore the protein C activity and cytochrome P4502C19 (CYP2C19) gene expression in the patients with acute deep vein thrombosis (DVT) to determine the relationship of these two genetic factors( protein C system and the expression of CYP2C19 ) with DVT and to study the role and importance on these both genetic factors in the pathogenesis of patients with DVT. Methods The protein C activity and expression of CYP2C19 gene were detected in 213 cases of DVT patients so as to mastering the hereditary protein C deficiency, CYP2C19 gene mutation affecting to the incidence and significance of DVT. Results The protein C activity decreased in the group of the patients with DVT with fractures, trauma, and surgical history primary decreased protein C activity compared with control group of 126 cases. The difference is statistically significant between two groups(P< 0.05). CYP2C19 gene variant including intermediary metabolism and slow metabolism had no significant distribution characteristic.The difference was not statistically signiifcant. Conclusion Hereditary protein C deifciencies plays an important role on the pathogenesis of the patients with DVT and CYP2C19 gene is also important for the prognosis of the patients with DVT. And no evidence showed that there’s relationship between the protein C and CYP2C19 gene expression in the patients with DVT.
出处
《临床普外科电子杂志》
2013年第4期17-20,共4页
Journal of General Surgery for Clinicians(Electronic Version)
