摘要
目的系统评估小儿脑性瘫痪诊断性研究的研究进展。方法以"脑性瘫痪、儿童、诊断等"为主题词,通过计算机检索包括中国学术文献总库、重庆维普中文科技期刊数据库、万方期刊及学位论文数据库、中国生物医学文献数据库(CBM)、EMBASE、MEDLINE、Pub Med、以及Cochrane图书馆临床对照试验数据库,并辅以文献追溯、手工检索等方法,尽可能收集2013年1月至今国内外公开发表的文章及学位论文中关于小儿脑性瘫痪诊断性研究的临床资料,并追查所有纳入研究的参考文献。按纳入排除标准纳入合格的随机对照研究并对其进行质量评价,采用Cochrane协作网提供的Revman 5.1软件进行Meta分析。结果共纳入文献3篇,其中包含1篇回顾性研究,2篇前瞻性研究。总样本量为851例,其中606例采用了神经学检查,240例进行了粗大运动发育评估,5例采用了影像学检查。本研究是以学龄前脑瘫儿童为代表性人群进行早期运动发育和大脑结构的研究。结论欲实现脑瘫的明确诊断,除了解患者病史、对其高危人群提高警惕外,联合应用多项检查方法亦至关重要。此外,儿科临床医生应该多查阅国内外关于脑瘫诊断的最新文献,及时学习新的研究成果,以期对脑瘫的指导治疗和判断预后提供客观依据。
Objective To the diagnosis of cerebral palsy,a meta-analysis was performed to review the evidence from the included trials regarding the research progress of diagnostic studies children with cerebral palsy. Methods We used certain Me SH such as cerebral palsy、children、child、diagnosis etc.Research from Academic literature database chongqing Chinese and Technology Periodical Database wan journals and Academic、Chinese Biomedical Literature、Database( CBM) 、EMBASE、MEDLINE、Pub Med,and Cochrane Library Clinical controlled trial database by the computer,at the same time,we made the fully use of the literature review and manual search. We tried our best to research all literatures on diagnosing of cerebral palsy from articles and degree thesises which published at home and abroad from Januray 2013 to now,and traced all the references included in this study. We assessed the quality of qualified randomised controlled studies according to the inclusion and exclusion criteria. Then we performed the meta-analysis by Rev Man 5. 1 provided by the Cochrane Collaboration. Due to heterogeneity of the included articles,we could not finish the appropriate forest plot. Therefore,descriptive analysis was performed in this study. Results Three articles were searched according to the inclusion and exclusion criteria. One retrospective study and two prospective studies were identified. The studies recruited a total of 851 patients. No age restrictions were imposed( ranging from six to sixty months). There were 606 patients with the neurological examinations,such as the Developmental Assessment of Young Children,the Bayley Scales of Infant Development exam. 240 children had gross motor function assessments which outcomes include gross motor function,Gross Motor Function Classification System,and so on. Children finished the diagnosis of cerebral palsy with the help of neuroimaging,such as a novel EEG-based brain mapping system、functional magnetic resonance imaging( f MRI). This study described a large population-based stu
出处
《中华诊断学电子杂志》
2013年第1期-,共4页
Chinese Journal of Diagnostics(Electronic Edition)
基金
国家自然科学基金(81271458)
江苏省医学重点人才基金(RC2011113)
关键词
脑性瘫痪
儿童
诊断
Cerebral palsy
Children
Diagnosis
