摘要
布鲁氏菌病是由布鲁氏菌引起的人兽共患病,给养殖业、人类健康和动物源性食品安全带来很大威胁。布鲁氏菌的IV型分泌系统在布鲁氏菌的致病力上发挥重要作用,与布鲁氏菌在宿主细胞内生存、复制有密切关系。IV型分泌系统由virB操纵子编码,由同一启动子调控,是一个多蛋白的跨膜复合物,受感染宿主细胞类型、生长温度、营养条件、pH值等多因素调控;并且对布鲁氏菌的胞内、胞外的生存产生重要影响。
Brucellosis,which is caused by Brucella,is one of the most important bacterial zoonoses.It brings serious harm to stock raising,human health and animal-derived food security.Type IV secretion system of Brucella is essential for survival and multiplication within the host cells,which also play an important role in pathogenicity of Brucella.Type IV secretion system that is encoded by the virB operon is described as a family of multi-protein and crossing-envelope complex,and regulated by the same promoter.Type IV secretion system is also affected by multi-factor,which may be PH,temperature,nutrition and the type of the cells infected and it plays an important role in regulation intracellular and extracellular survival of Brucella.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2012年第9期951-954,共4页
Chinese Journal of Zoonoses
