摘要
采用硫酸镓为催化剂合成了对羟基苯甲酸己酯,考察了催化剂用量、酸醇物质的量比、回流反应时间、催化剂重复使用性及带水剂种类等因素对产物收率的影响。结果表明硫酸镓具有催化活性高,反应时间短,合成工艺流程简单,操作方便。适宜反应条件为:对羟基苯甲酸0.05mol,对羟基苯甲酸与正己醇物质的量比1:3,催化剂硫酸镓用量2.0g,反应时间2h,10mL环己烷作带水剂,对羟基苯甲酸己酯收率为97.3%。
P-hydroxybenzoic acid and n-hexanol reacted to form n-hexyl p-hydroxybenzoate with gallium sulphate as the catalyst.Factors influencing the yield were discussed.That conclueded amount of catalyst,reaction time,molar ratio of alcohol to acid and repeated uses.The catalyst had many advantages such as insoluble in reaction system,high activity,short reaction time and easy post treatment process.It was also non-pollutional to the environment.The best conditions were p-hydroxybenzoic acid 0.05mol,molar ratio of acid to alcohol 1:3,the catalyst gallium sulphate 2.0g,10mL cyclohexane and reaction time 2 h,the yield can reach 97.3%.It was the efficient,economic and environmental friendly catalyst.
关键词
尼泊金己酯
硫酸镓
催化
合成
n-hexyl p-hydroxybenzoate
gallium sulphate
catalysis
synthesis.
