摘要
Objective To explore the clinicopathologic features of angiomyofibroblastomz and the relationship between angiomyofibroblastoma (AMFB)and aggressive angiomyxoma (AA ). Aethods Seven cases of AMFB and 5 coses of AA were reviewed. Conventional histologic and immunohistochemical features of AMFB were compered with those of AA. Results The lesions of AMFB usually presented as painless masses and were located in the superficial vulvar regional and inguinal areas. Microscopically, the tumors were composed of spindled and epithelioid cells arranged in cords and nests preferentially arrayed around numerous small to medium-sized, thin-walled vessels with some hyalined thick walls. Seven cases manifested zone of both dense and sparse cellularity. Immunohistochemically, the tumor cells were strongly positive for vimentin and desmin. but negative for S-100 and cytokeratin 8. Some cells were positive for SMA, ER and PR. None of the 4 ams followed up over 2 years after simple excision developed a recurrence, in contract to AA that exhibited local recurrence in 3 of 4 cases. AA showed more dense myxoid hackground and thick walled vessels. Myoid bundles tended to be located adjacently to biood vessels in all cases. Ultrastructurally,AMFB tumor cells contained intercellular junction and cytoplastic microfilaments. Intercellular spaces contained a great of collagen fibers. Conclusion The results indicate that conventional morphologic analysis is paramount in the recognition of ANFB. AMFB and AA show different clinicoathologic entity and propose an origin from a perivascular stem cell that is ca- pable of myofibroblastic differentiation.
Objective To explore the clinicopathologic features of angiomyofibroblastoma and the relationship between angiomyofibroblastoma (AMFB)and aggressive angiomyxoma (AA). Methods Seven cases of AMFB and 5 cases of AA were reviewed. Conventional histologic and immunohistochemical features of AMFB were compared with those of AA. Results The lesions of AMFB usually presented as painless masses and were located in the superficial vulvar regional and inguinal areas. Microscopically, the tumors were composed of spindled and epithelioid cells arranged in cords and nests preferentially arrayed around numerous small to medium-sized, thin-walled vessels with some hyalined thick walls. Seven cases manifested zone of both dense and sparse cellularity. Immunohistochemically , the tumor cells were strongly positive for vimentin and desmin , but nega tive for S-100 and cytokeratin 8. Some cells were positive for SMA ,ER and PR. None of the 4 cases followed up over 2years after simple excision developed a recurrence, in contract to AA that exhibited local recurrence in 3 of 4 cases. AA showed more dense myxoid background and thick walled vessels. Myoid bundles tended to be located adjacently to blood vessels in all cases. Ultra structurally,AMFB tumor cells contained intercellular junction and cytoplastic microfilaments. Intercellular spaces contained a great of collagen fibers. Conclusion The results indicate that conventional morphologic analysis is paramount in the recogni tion of AMFB. AMFB and AA show different clinicoathologic entity and propose an origin from a perivascular stem cell that is ca pable of myofibroblastic differentiation.
