摘要
目的探讨细胞间黏附分子 -1 (Intercellular adhesion molecule-1, ICAM-1) 基因 K469E 多态性与冠心病的关联性。方法全面检索中英文数据库关于 K469E 多态性与冠心病遗传易感性关系的病例对照研究,采用 Meta 分析方法合并 K469E 与冠心病关联的 OR 值,结合 95% CI 作为每个研究结果的研究效应测定指标。结果共纳入文献 13 篇。对于东亚人群,共纳入病例 1 181 例,对照 1 347 例,基因型(KK+KE)/EE 合并 OR=1.99 (95% CI: 1.32-3.00,P<0.05) ;对于高加索人群,共纳入病例 1 480 例,对照 1 182 例,基因型 (KK+KE)/EE 合并 OR=1.20 (95% CI: 0.56-2.59,P>0.05)。结论 K469E 是东亚人冠心病的遗传危险因素,而与高加索人冠心病的发生无关联。
Objective To investigate the association between the polymorphism of ICAM-1 gene K469E and risk of coronary artery disease(CAD).Methods Association studies were identified from the databases of PubMed,EMbase,CNKI and Wanfang and pooled effects(OR together with 95% CI) were calculated.Results Thirteen studies were reviewed.The pooled OR of 469K compared to E allele was OR=1.99(95% CI:1.32-3.00,P<0.05) in East Asian group.The pooled OR of 469K compared to E allele was OR=1.20(95% CI:0.56-2.59,P>0.05) in Caucasian group.Conclusion The K469E is a risk factor of CAD in East Asian population,while it is not associated with CAD in Caucasian population.
出处
《中国分子心脏病学杂志》
CAS
2011年第5期276-280,共5页
Molecular Cardiology of China
基金
国家973重点基础研究发展规划基金(2011CB503901)
国家自然科学基金(30971159)
