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多糖激活巨噬细胞的信号转导通路 被引量:9

Polysaccharides activate signaling pathways of macrophage
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摘要 多糖是一类来源广泛,通过多途径多机制激活巨噬细胞而发挥免疫调节功能的天然活性物质。阐明来源不同(植物、真菌、藻类)的多糖激活巨噬细胞的信号传导通路,不仅有助于从分子水平了解其调节免疫功能的作用机制,也可为新型靶向免疫调节药物的开发提供新的方向。 Polysaccharides extracted from various sources are natural active substances,which may lead to the activation of macrophage via multiple pathways and mechanisms.This article intends to illustrate the signaling pathways of polysaccharides from plants,fungi,algae and other sources,to indentify the mechanisms on the molecular level,and to explore the novel target immunomodulatory agents.
出处 《浙江大学学报(医学版)》 CAS CSCD 北大核心 2011年第5期567-572,共6页 Journal of Zhejiang University(Medical Sciences)
关键词 多糖类/药理学 巨噬细胞/免疫学 信号传导 Polysaccharides Macrophages/immunol Signal Transduction
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  • 1李明春,梁东升,许自明,雷林生,杨淑琴.灵芝多糖对小鼠巨噬细胞cAMP含量的影响[J].中国中药杂志,2000,25(1):41-43. 被引量:60
  • 2R.W. Birk,A. Gratchev,N. Hakiy,O. Politz,K. Schledzewski,P. Guillot,C.E. Orfanos,S. Goerdt.Alternative Aktivierung antigenpr?sentierender Zellen Konzept und klinische Bedeutung[J]. Der Hautarzt . 2001 (3) 被引量:1
  • 3DONG L,XIA S H,LUO Y,et al.Targeting deliveryoligonucleotide into macrophages by cationicpolysaccharide from bletilla striata successfullyinhibited the expression of TNF-alpha. Journal of Controlled Release . 2009 被引量:1
  • 4LO T C T,JIANG Y H,CHAO A L J,et al.Use ofstatistical methods to find the polysaccharidestructural characteristics and the relationshipsbetween monosaccharide composition ratio andmacrophage stimulatory activity of regionallydifferent strains of Lentinula edodes. Analytica Chimica Acta . 2007 被引量:1
  • 5OBERG F,HASEEB A,AHNFELT M,et al.Herbalmelanin activates TLR4/NF-kappa B signalingpathway. Phytomedicine . 2009 被引量:1
  • 6PARK H J,HONG J H,KWON H J,et al.TLR4-mediated activation of mouse macrophages byKorean mistletoe lectin-C (KML-C). Biochemical and Biophysical ResearchCommunications . 2010 被引量:1
  • 7LI X,W X U.TLR4-mediated activation ofmacrophages by the polysaccharide fraction frompolyporus umbellatus (pers.)fries. JEthnopharmacol . 2010 被引量:1
  • 8LISA A PRICE,CYNTHIA A WENNER,DANIELT SLOPER,et al.Role for toll-like receptor 4 inTNF-alpha secretion by murine macrophages inresponse to polysaccharide Krestin,a Trametesversicolor mushroom extract. Fitoterapia . 2010 被引量:1
  • 9YIN X L,CHEN L,LIU Y,et al.Enhancement ofthe innate immune response of bladder epithelialcells by astragalus polysaccharides throughupregulation of TLR4 expression. Biochemicaland Biophysical Research Communications . 2010 被引量:1
  • 10TAKEUCHI O,S AKIRA.Pattern recognitionreceptors and inflammation. Cell . 2010 被引量:1

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