摘要
长非编码RNA(lncRNA)是新发现的RNA干扰方式,与其他包括DNA甲基化、组蛋白修饰、染色质重构等表观遗传形式一样,在恶性肿瘤的发生和发展中起着重要作用。近年分子肿瘤学研究显示,lncRNA与其他表观遗传形式相互作用,如lncRNA可通过多种途径调控DNA甲基化、组蛋白修饰、染色质重构和其他RNA干扰形式,而DNA甲基化、染色质重构等也可调控lncRNA的表达及作用;其错综复杂的网路关系影响肿瘤的发生和发展。
As a newly discovered RNA interference method,long noncoding RNAs(lncRNA) play an important role in the development and progression of carcinomas,just as other epigenetic mechanisms including DNA methylation,histone modifications and chromatin remodeling.Recent researches have highlighted that lncRNA can interact with other epigenetic mechanisms.lncRNA can regulate DNA methylation,histone modifications,chromatin remodeling and other RNA interference through many ways,and the expression and role of lncRNA can be regulated by DNA methylation and chromatin remodeling.The complex relationship affects the development and progression of carcinomas.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2011年第7期1022-1026,共5页
Journal of Shanghai Jiao tong University:Medical Science
