摘要
血浆置换(PE)联合连续血液净化(CBP)对小儿溶血尿毒综合征(HUS)的疗效观察及机制探讨。回顾性分析21例重型HUS患儿在内科综合治疗同时,采用序贯血浆置换(PE)加连续性静-静脉血液滤过(CVVH)治疗前后生命体征、炎性细胞因子、生化指标等的变化。经序贯PE加CBP治疗后患儿全身状况迅速改善,溶血控制,尿量增加,肾及其他各脏器功能检测指标逐步恢复正常,治疗前后炎性细胞因子、生化指标等具有显著差异。说明PE联合CBP救治重型溶血尿毒综合征能显著清除致病性细胞因子,稳定内环境,改善内皮细胞功能增强疗效,尽早治疗可缩短病程,改善预后。
To discuss the mechanism of sequential plasma exchange(PE) and continuous blood purification(CBP) in the treatment of children hemolytic uremic syndrome(HUS) as well as the therapeutic effectiveness.The change in vital sign,some cytokine and biochemical indicator before and after PE+CBP treatment in 21 cases of HUS with conventional treatment were analyzed.After PE+CBP,rapid improvement occurred in systematic conditions,hemolytic control,urine increase.Functions of kidney and other organs gradually recovered to normal,they were all survived patients at acute phase and hemolytic control,the function of kidney and other organ recovered.There were significantly differences in some cytokine and biochemical indicator before and after PE and CBP treatment.PE+CBP treat hemolytic uremic syndrome can significantly remove some of the pathogenic cytokines,stablize internal environment,improve endothelial cell function to enhance efficacy,early treatment can shorten the course of the disease and improve prognosis.
出处
《生物医学工程研究》
2011年第1期46-48,55,共4页
Journal Of Biomedical Engineering Research
关键词
血浆置换
连续血液净化
溶血尿毒综合征
小儿
内皮细胞
Plasma exchange
Continuous blood purification
Hemolytic uremic syndrome
Paediatrics
Vascular endothelial cells
