摘要
24只苏禽黄羽肉鸡随机分成2组,分别按10 mg/kg体重剂量静注和内服乳酸恩诺沙星。测定乳酸恩诺沙星在鸡体内的药动学参数和生物利用度。恩诺沙星血药浓度数据用3p87计算机软件处理。静注乳酸恩诺沙星后的血药浓度-时间数据符合二室开放模型,主要动力学参数:t1/2α(0.45±0.16)h,t1/2β(7.02±1.42)h,CL(s)(0.38±0.10)L/kg/h,AUC(23.69±5.56)(mg/L)×h。内服乳酸恩诺沙星的血药浓度时间数据,符合有吸收因素二室模型,主要动力学参数:t1/2ka(0.60±0.01)h,t1/2ke(8.25±1.73)h,tpeak(2.44±0.17)h,Cmax(1.44±0.30)mg/L,AUC(20.74±3.80)(mg/L)×h,F 87.54%。结果表明,乳酸恩诺沙星可溶性粉在鸡体内具有吸收快、分布广、消除较慢以及内服生物利用度高的药动学特征。
The pharmacokinetics and bioavailability of enrofloxacin lactate were investigated in 24 healthy Suqin yellow chickens following single intravenous and oral(10 mg/kg b.w.) administration.The concentrations of enrofloxacin lactate were determined by high-performance liquid chromatography(HPLC) and the plasma concentration-time data was analyzed by the pharmacokinetic computer program 3p87.Following intravenous administration,the drug concentration-time data was best described by a two-compartment open model....
出处
《畜牧与兽医》
北大核心
2010年第9期27-30,共4页
Animal Husbandry & Veterinary Medicine
关键词
乳酸恩诺沙星
药动学
鸡
生物利用度
enrofloxacin lactate
pharmacokinetics
chicken
bioavailability
