摘要
目的探讨慢性丙型肝炎病毒(HCV)感染患者T细胞亚群水平以及与丙型肝炎病毒复制的关系。方法以间接免疫荧光一流式细胞仪、ELISA法和RT-PCR检测了26例慢性HCV感染患者外周血T细胞亚群(其中HCV-RNA阳性17例,HCV-RNA阴性9例)。结果慢性HCV感染患者外周血CD_4^+淋巴细胞亚群,CD_4^+/CD_8^+比值明显低于正常对照组(P<0.01)。血清HCV-RNA阳性患者的CD_4^+/CD_8^+比值明显低于HCV-RNA阴性患者(P<0.05)。结论提示细胞免疫功能受抑制可能是HCV持续感染的原因。
Objective To investigate the relationship between cellular immue function and the chronic HCV infection. Methods Peripheral blood T-Lymphocyte subsets were determined by indirect immuno-fluore scence and ELISA and RT-PCR in 26 patients with chronic HCV infection (of which 17 cases were HCV-RNA positive and 28 cases HCV-RNA negative). Results It was found that the CD_4^+/CD_8^+ T cell subsets, CD_4^+/CD_8^+ ratio were significantly lower than those of the controls, CD_4^+/CD_8^+ ratio of HVC RNA positve cases were signiicantly lower than those of the HCV-RNA negative cases. Conclvsion It suggests that suppression of the call mediated immunity might be the cause of HCV persistant infection.
出处
《热带病与寄生虫学》
2001年第1期23-24,共2页
Journal of Tropical Diseases and Parasitology
