摘要
干细胞抗原1(Sca-1)是干细胞的一种重要表面标记物,体内许多干细胞都表达Sca-1。同样,心肌干细胞也表达Sca-1。目前研究发现,Sca-1+心肌干细胞能够分化为心肌细胞,对心肌梗死后心室重构与心肌再生具有明显作用,能够促进心脏的修复。因此,Sca-1+心肌干细胞有可能使心肌梗死的临床治疗取得实质性的进展。现综述了Sca-1+心肌干细胞的来源、分化、作用等方面。
Stem cell antigen-1(Sca-1) is an important surface marker for stem cells;cardiac myocytes,and other somatic stem cells express Sca-1.Recently,a number of reports have suggested that Sca-1+ cardiac stem cells were capable of differentiating into cardiac myocytes,which were significantly contributing to post myocardial infarction(post-MI) left ventricular remodeling and myocardium regeneration,and which could promote cardiac repair.Accordingly,Sca-1+ cardiac stem cells might lead to clinically useful therapie...
出处
《心血管病学进展》
CAS
2009年第6期1047-1050,共4页
Advances in Cardiovascular Diseases
关键词
干细胞抗原1
心肌干细胞
分化
心肌细胞
stem cell antigen-1
cardiac stem cells
differentiation
cardiac myocytes
