摘要
目的研究免疫治疗后特异性免疫球蛋白E(specific immunoglobulin E,sIgE)浓度变化,是否下降。方法从明确屋尘螨过敏并进行屋尘螨特异性免疫治疗的患者中,随机抽取35例,检测屋尘螨sIgE,按时间段分为4组,与治疗前进行比较。结果各组升高者居多,但差异无统计学意义。从总体看,免疫治疗后sIgE升高(P<0.05)。结论免疫治疗可以升高sIgE,不能以sIgE下降作为评价免疫治疗疗效的免疫学标志。
Objective To study the changes of the concentration of allergen-specific IgE after allergen specific immunotherapy.Methods Among the patients allergic to Dermatophagoides pteronyssinus(house dust mite)and being receiving immunotherapy,who were devided into 4 groups by the treat course,35 were randomly tested for allergen-specific IgE.The specific immunoglobulin E(sIgE)results were compared with those before immunotherapy. Results Allergen-specific IgE in each group tended to increase,but there was no statistical difference.As a whole,the sIgE increased statistically after immunotherapy.Conclusion Allergenspecific IgE may increase in patients receiving immunotherapy,and the decrease of sIgE cannot act as a marker of efficacy of specific immunotherapy.
出处
《河北医科大学学报》
CAS
2009年第10期1032-1033,共2页
Journal of Hebei Medical University
关键词
免疫
生物学标记
尘螨科
immunity
biological marker
pyroglyphidae
