摘要
目的:观察双氢杨梅素(DMY)对小鼠肠缺血-再灌注损伤(IIRI)过程中一氧化氮含量的影响,探讨双氢杨梅素对肠缺血-再灌注损伤的保护作用。方法:昆明种小鼠随机分为五组:①正常对照组;②肠缺血再灌注(IIR)组;③~⑤低、中、高剂量双氢杨梅素(DMY50,100,200mg/kg)+肠缺血再灌注组。采用BI-2000图像分析系统观察小鼠肠系膜血管微循环的变化情况,硝酸还原酶法测定小鼠血浆和小肠一氧化氮(NO)水平。结果:经DMY处理后,小肠微循环明显改善,血浆、小肠NO水平呈剂量依赖性升高,三个剂量组NO值均高于IIR组(P<0.05)。结论:双氢杨梅素对小鼠肠缺血-再灌注损伤具有保护作用,作用机制可能与提高NO水平有关。
Objective To observe the changes of Nitric oxide(NO) and explore the mechanism of protective effect of dihydromyricetin(DMY) against intestine ischemia-reperfusion injury(IIRI) in mice.Methods The experimental mice were divided into five groups randomly: normal control group;model group(IIR);DMY(50,100,200 mg/kg) + IIR;During the experimental,the microcirculation of mesentery vas was observed by BI-2000 image analysis system.At the end of the experiments,the content of NO was determined in mice intestine ho...
出处
《湖南师范大学学报（医学版）》
2006年第3期8-10,共3页
Journal of Hunan Normal University(Medical Sciences)
基金
湖南省卫生厅科研基金资助项目(B2005-006)
关键词
双氢杨梅素
小肠
缺血-再灌注损伤
一氧化氮
dihydromyricetin
intestines
ischemia-reperfusion injury
nitric oxide
