摘要
目的 比较万拉法新与舒必利辅助治疗精神症阴性症状的效果。方法 使用万拉法新、舒必利分别作为氯氮平的辅助用药,对84例以阴性症状为主的分裂症患者进行对照研究,以简明精神量表(BPRS)、阴性症状量表(SANS)、汉密尔顿抑郁量表(HAMD)和副反应量表(TESS)进行评定。结果两组有效率分别为73.79％、76.19％,无显著性差异,治疗4周后BPRS、SANS、HAMD和TESS比较有显著性差异(P<0.05),治疗8周后HAMD差异非常显著(P<0.01),BPRS有显著性差异(P<0.05),而SANS和TESS无显著性(P>0.05)。万拉法新的主要不良反应为口干、出汗、恶心及头痛等症状,一般不须处理。结论 在服氯氮平的基础上,用万拉法新作为治疗精神分裂症阴性症状的辅助药,比舒必利更安全、副反应小。
Objectives:To compare Venlafaxine Versus Sulpiride as adjunct in the treatment of negative symptoms in schizophrenic patients. Method: 84 schizophrenic patients with negative symptoms were treated with Venlafaxine or Sulpiride as adjunct to clozapine. All the patients were assessed with BPRS, SANS, HAMD, TESS assessment. Results: The effective rate of each group was 73. 79% ,76. 19% respectively GP>0. 05), without significant difference. The scores of SANS,BPRS,HAMD and TESS showed marked differences in Wk4 (P<0. 05); HAMD scores of the two groups were significantly different in wk8 (P<0. 01), while BPRS scores were different (P<0. 05), but SANS and TESS showed no difference (P>0. 05). The main adverse effects of Venlafaxine were thirst,sweating,nausea,headache which didn't need to be dealed with. Conclusion: Venalfaxine appeared to have a better safety and side effect profile comparing with sulpiride as an adjunct adding on clozapine.
出处
《上海精神医学》
北大核心
2003年第1期39-41,共3页
Shanghai Archives of Psychiatry
关键词
万拉法新
舒必利
阴性症状
Venlafaxine Sulpiride Negtive symptoms
