摘要
目的:研究应用大剂量抑肽酶在长时间体外循环中对于出血量、输血量及血小板的影响。方法:选取两组病例各30例,一组应用抑肽酶作为实验组,另一组不用抑肽酶作为对照组,观察它们在CPB术中、术后总输血量、总引流量,分别记录其术前、术后血小板的变化。结果:实验组总输血量、总引流量较对照组减少(均P<0.05),有显著性差异;两组病例术后血小板均较术前减少(均P<0.001),而两组病例术前、术后血小板比较无差异(均P>0.05)。结论:在长时间CPB中应用大剂量抑肽酶能明显减少输血量,但对血小板数量无明显影响。
Objective To study the effect of large dose of ap rotinin on the amount of haemorrhage,blood infusion and BPC in long time cardiopulmonary byp ass(CPB).Methods60patients were invovled in this stu dy and divided into two groups,one was experimental group with aprotinin,and the other used as c ontrol without aprotinin.The total amount of blood infusion and drainage were observed during and after operation.The change of BPCbefore and after opera tion was compared.Results The total amount of blood infusion an d drainage in the experimental group was significantly less than those in control group(P <0.05).The amount of BPC was decreased afte r operation in both groups compared with preoperation(P <0.001),while no significant difference wa s found between these two groups(P>0.05).Conclusion The amount of blood infusion could be reduced greatly with the administra tion of large dose of aprotinin in lon g time CPB,howerever,it has no effect on th e amount of BPC.
出处
《安徽卫生职业技术学院学报》
2002年第2期17-18,共2页
Journal of Anhui Health Vocational & Technical College
关键词
体外循环
抑肽酶
cardiopulmonary bypass
aprotinin
